We are currently experiencing a rapidly developing era in terms of translational and clinical medical sciences. The relatively mature state of nucleic acid examination has significantly improved our understanding of disease mechanism and therapeutic potential of personalized treatment, but misses a large portion of phenotypic disease information. Proteins, in particular phosphorylation events that regulates many cellular functions, could provide real-time information for disease onset, progression and treatment efficacy. The technical advances in liquid chromatography and mass spectrometry have realized large-scale and unbiased proteome and phosphoproteome analyses with disease relevant samples such as tissues. However, tissue biopsy still has multiple shortcomings, such as invasiveness of sample collection, potential health risk for patients, difficulty in protein preservation and extreme heterogeneity. Recently, extracellular vesicles (EVs) have offered a great promise as a unique source of protein biomarkers for non-invasive liquid biopsy. Membranous EVs provide stable preservation of internal proteins and especially labile phosphoproteins, which is essential for effective routine biomarker detection. To aid efficient EV proteomic and phosphoproteomic analyses, recent developments showcase clinically-friendly EV techniques, facilitating diagnostic and therapeutic applications. Ultimately, we envision that with streamlined sample preparation from tissues and EVs proteomics and phosphoproteomics analysis will become routine in clinical settings.

Xiaofeng Wu

Anton B Iliuk

W Andy Tao

Advances in clinical chemistry

临床化学卷的进展包含学术界和临床实验室科学领域领先专家的材料。这些评论涵盖了广泛的临床化学学科，包括临床生物标志物探索、尖端微阵列技术、蛋白质组学和基因组学。它是临床化学、分子诊断学、病理学和临床实验室科学从业人员不可或缺的资源和实用指南。

Advances in Clinical Chemistry is a significant journal in the field of clinical chemistry, featuring contributions from leading experts in academia and clinical laboratory sciences. The reviews cover a wide range of topics in clinical chemistry, including the exploration of clinical biomarkers, cutting-edge microarray technologies, proteomics, and genomics. This journal serves as an indispensable resource and practical guide for professionals in clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences.

《Advances in Clinical Chemistry》是临床化学领域的重要期刊，涵盖了学术界和临床实验室科学领域的领先专家撰写的研究材料。这些评论涉及广泛的临床化学主题，包括临床生物标志物的探索、前沿的微阵列技术、蛋白质组学和基因组学。该期刊是临床化学、分子诊断学、病理学和临床实验室科学从业人员不可或缺的资源和实用指南。

Advances in Clinical Chemistry

Adv Clin Chem

Translational proteomics and phosphoproteomics: Tissue to extracellular vesicles.

It is envisioned that with streamlined sample preparation from tissues and EVs proteomics and phosphoproteomics analysis will become routine in clinical settings.

Category	Quartile
医学	2
医学, 医学实验技术	1

Translational proteomics and phosphoproteomics: Tissue to extracellular vesicles.

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