Background: Mesothelioma is an aggressive malignancy of the serosal surfaces with very poor prognosis. It traditionally manifests in older patients and at an advanced stage which results in minimal improvement in prognosis despite the recent advances in management. Early detection would therefore significantly impact management and potentially improve survival. Mesothelioma frequently presents with recurrent effusions, posing cytology as the initial procedure in the workup. A definitive diagnosis would not only spare the patients additional diagnostic procedures but also potentially afford them an opportunity for early surgical intervention and therapy. Summary: In this article we review the role of immunocytochemistry (ICC) in the work up of mesothelioma. The various ICC markers to confirm or rule out mesothelial lineage are reviewed. In addition, newly introduced molecular surrogates that confirm the malignant nature of the mesothelial cells and support a definitive diagnosis of mesothelioma are discussed. We also briefly discuss the theranostic implications of such markers and potential impact of such recent advances on the cytological diagnosis and reporting of mesothelioma. Key messages: The cytological diagnosis of mesothelioma no longer requires the extensive expertise in morphological analysis and can be offered based on supporting ICC that confirms the mesothelial lineage and malignant nature of the cells.

Claire W. Michael

Shannon Alexandra Rodgers

Acta Cytologica

凭借在临床细胞学和细胞病理学之间提供出色平衡的文章，“细胞学学报”促进了对细胞形态学背后发病机制的理解，从而促进了将一线研究转化为临床实践。作为国际细胞学学会的官方期刊，隶属于全球 50 多个国家细胞学学会，《细胞学学报》评估了科学进步的新的和现有的诊断应用及其临床相关性。原创论文、评论文章、荟萃分析、临床实践的新见解以及致编辑的信函涵盖了从诊断细胞病理学、妇科和非妇科细胞病理学到细针穿刺、分子技术及其诊断应用的主题。作为实用的完美参考，《细胞学学报》面向从事临床细胞病理学、细胞生物学、肿瘤学、介入放射学、耳鼻喉科、胃肠病学、泌尿学、肺病学和预防医学的多学科受众。

The journal Acta Cytologica provides excellent articles that bridge the fields of clinical cytology and cytopathology, enhancing the understanding of the pathophysiological mechanisms behind cellular morphology and facilitating the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology, it is affiliated with cytology societies in over 50 countries worldwide, evaluating the scientific advancements in both new and existing diagnostic applications and their clinical relevance. The journal features original research articles, review articles, meta-analyses, new insights into clinical practices, and letters to the editor, covering a wide range of topics from diagnostic cytopathology, gynecological and non-gynecological cytopathology, to fine needle aspiration, molecular techniques, and their diagnostic applications. Serving as a practical reference, Acta Cytologica caters to a multidisciplinary audience engaged in clinical cytopathology, cell biology, oncology, interventional radiology, otolaryngology, gastroenterology, urology, pulmonology, and preventive medicine.

《Acta Cytologica》期刊在临床细胞学和细胞病理学领域提供了优秀的文章，促进了对细胞形态学背后发病机制的理解，从而推动了一线研究向临床实践的转化。作为国际细胞学学会的官方期刊，该期刊隶属于全球50多个国家的细胞学学会，评估了科学进步在新的和现有的诊断应用及其临床相关性方面的影响。期刊内容包括原创论文、评论文章、荟萃分析、临床实践的新见解以及致编辑的信函，涵盖了从诊断细胞病理学、妇科和非妇科细胞病理学到细针穿刺、分子技术及其诊断应用的多个主题。作为实用的参考资料，《Acta Cytologica》面向从事临床细胞病理学、细胞生物学、肿瘤学、介入放射学、耳鼻喉科、胃肠病学、泌尿学、肺病学和预防医学等多个学科的研究人员。

Category	Quartile
医学	4
医学, 病理学	4

Role of Immunocytochemistry in The Cytological Diagnosis of mesothelioma

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