Phage therapy has regained value as a potential alternative and a complementary anti-infective approach to antibiotics in the fight against bacterial pathogens. Due to their host specificity, non-pathogenic nature for humans, and low production cost, phages offer an effective opportunity for utilization in healthcare, agriculture, and food preservation. Well-defined storage conditions are essential for commercialization and dissemination of phage usage. For this purpose, in our study, after the isolation and characterization of two different phages, one lytic and the other lysogenic; storage and shelf-life studies of phages were evaluated in a presence of various protectants (glycerol, sodium azide, DMSO with chloroform) and without any protectant during 8-month period at four different temperatures. The short-time stability of the lytic P. syringae phage and lysogenic MRSA phage, which were determined by STEM analysis to belong to the Straboviridae and Siphoviridae families, respectively were also examined for the different temperatures and the pH levels ranging from 1.0 to 14.0. This study revealed the storage-model of phages that exhibit distinct lifecycles, for the first time and provided a theoretical basis for development and application of phages, has yielded valuable findings contributing to understanding of phage biology.

Emine Selcuk

Senanur Dokuz

Tulin Ozbek

Journal of pharmaceutical sciences

JOURNAL OF PHARMACEUTICAL SCIENCES 将发表原创研究论文、原创研究笔记、特邀专题评论（包括 MINIREVIEWS）以及社论评论和新闻。重点领域应为基础药物科学概念和药物化学加工等主题，包括结晶、冻干、药物化学稳定性、药代动力学、生物药剂学、药效学、前药开发、生物活性剂的代谢处置、剂型设计、蛋白质-肽化学和生物技术，特别是因为这些与制药技术和靶向药物输送有关。

The Journal of Pharmaceutical Sciences publishes original research articles, original research notes, invited topical reviews (including mini-reviews), as well as editorial comments and news. The focus areas should include fundamental concepts of pharmaceutical sciences and drug chemistry processing, covering topics such as crystallization, lyophilization, drug chemical stability, pharmacokinetics, biopharmaceutics, pharmacodynamics, prodrug development, metabolic disposition of bioactive agents, formulation design, protein-peptide chemistry, and biotechnology, particularly as they relate to pharmaceutical technology and targeted drug delivery.

《Journal of Pharmaceutical Sciences》将发表原创研究论文、研究笔记、特邀专题评论（包括小型综述）以及社论评论和新闻。重点领域包括基础药物科学概念和药物化学加工等主题，涵盖结晶、冻干、药物化学稳定性、药代动力学、生物药剂学、药效学、前药开发、生物活性剂的代谢处置、剂型设计、蛋白质-肽化学和生物技术，特别是与制药技术和靶向药物输送相关的研究。

Journal of Pharmaceutical Sciences

J Pharm Sci

Evaluating the Stability of Lytic and Lysogenic Bacteriophages in Various Protectants.

This study revealed the storage-model of phages that exhibit distinct lifecycles, for the first time and provided a theoretical basis for development and application of phages, and yielded valuable findings contributing to understanding of phage biology.

Category	Quartile
医学	3
医学, 药物化学	3
医学, 化学综合	3
医学, 药学	3

Evaluating the Stability of Lytic and Lysogenic Bacteriophages in Various Protectants.

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	2