Digestive disorders following selective vagotomy and total vagotomy were compared in 2 groups of animals. The parasympathetic nerve supply intervenes in the regulation of the exocrine secretion of the pancreas mainly during the first 30 min after meals. This phase is maintained following selective vagotomy but is abolished by total vagotomy. A study of digestion at various levels of the small intestine shows that the latter is reduced in the duodenum after selective vagotomy, but compensatory mechanisms exist lower down. After total vagotomy, the disturbances were more significant. However, the ileum partially compensates. In man, this mechanism does not always exist after total vagotomy. The patient then has steatorrhea. Such disorders have never been observed ater selective vagotomy.

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