Chikungunya virus (CHIKV), prevalent in tropical regions, is known for causing frequent outbreaks, particularly in Central Africa, South America, and Southeast Asia. It is an arbovirus transmitted by the Aedes ( Ae. ) aegypti and Ae. albopictus mosquitoes. Infections lead to severe joint and muscle pain, which can linger and significantly impair an individual’s health, quality of life, and economic stability. Recent climatic changes and the globalization of travel have facilitated the worldwide spread of these mosquitoes. Currently, no U.S. Food and Drug Administration (FDA) approved drug is available for treating CHIKV infection. Recently, the FDA approved a live, attenuated vaccine called Ixchiq. However, this vaccine has been linked to side effects, leading the FDA to mandate additional post-marketing studies to assess the risk of severe adverse reactions similar to the virus. An emerging strategy in drug development focuses on targeting host factors that the virus exploits rather than the viral proteins themselves. This review explores the interactions between CHIKV and host factors that could be potential therapeutic targets. Despite progress in understanding the life cycle of CHIKV, the immune system’s role in combating the virus still needs to be fully understood. Investigating treatments that enhance the host’s immune response may offer new paths to combating CHIKV.

Nur Amelia Azreen Binti Adnan

Nida Kalam

Gabriel Lim Zi Jiunn

Thamil Vaani Komarasamy

Vinod R. M. T. Balasubramaniam

American Journal of Tropical Medicine and Hygiene

美国热带医学与卫生杂志成立于 1921 年，由美国热带医学与卫生学会每月出版。它是世界顶级热带医学期刊之一，发表原创科学文章和涵盖新研究的最新科学，重点关注人口、临床和实验室科学以及热带医学、寄生虫学、免疫学等领域的技术应用。传染病、流行病学、基础和分子生物学、病毒学和国际医学。该杂志发表未经请求的同行评审手稿、评论文章、简短报告、临床热带医学中的图像、案例研究、关于新药疗效和治疗方法的报告, 预防和控制方法, 新的检测方法和设备, 书籍报告和致编辑的信。主题范围从艾滋病等相关领域的应用流行病学到疫苗开发的分子生物学。该杂志对关注热带地区和发展中国家健康问题的流行病学家、寄生虫学家、病毒学家、临床医生、昆虫学家和公共卫生官员感兴趣和新出现的传染病。主要资助机构，包括活跃于公共卫生领域的慈善机构和政府机构，以及世界各地的医学和科学图书馆都购买该期刊。每年出版两份或更多关于特别感兴趣的主题的期刊增刊。这些增刊代表了对热带病专家关注的问题和发展中国家的健康问题的全面和多学科讨论

The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is one of the world's leading journals in tropical medicine, publishing original scientific articles and covering the latest scientific research, with a focus on the application of techniques in areas such as population studies, clinical and laboratory sciences, tropical medicine, parasitology, and immunology. The journal addresses topics including infectious diseases, epidemiology, basic and molecular biology, virology, and international medicine. It publishes unsolicited peer-reviewed manuscripts, review articles, brief reports, images in clinical tropical medicine, case studies, reports on the efficacy of new drugs and treatments, prevention and control methods, new diagnostic methods and devices, book reviews, and letters to the editor. The subject matter ranges from applied epidemiology related to diseases like AIDS to the molecular biology of vaccine development. The journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists, and public health officials who focus on health issues in tropical regions and developing countries, as well as researchers studying emerging infectious diseases. Major funding agencies, including charities and government organizations active in public health, as well as medical and scientific libraries worldwide, subscribe to the journal. Each year, two or more supplements on topics of special interest are published, representing comprehensive and multidisciplinary discussions on issues of concern to tropical disease experts and health problems in developing countries.

《American Journal of Tropical Medicine and Hygiene》创刊于1921年，由美国热带医学与卫生学会每月出版。作为全球顶尖的热带医学期刊之一，该杂志发表原创科学研究文章，涵盖最新的科学发现，重点关注人口、临床和实验室科学，以及热带医学、寄生虫学、免疫学等领域的技术应用。内容涉及传染病、流行病学、基础和分子生物学、病毒学和国际医学等多个领域。该杂志接受未经请求的同行评审手稿、评论文章、简短报告、临床热带医学中的图像、案例研究、新药疗效和治疗方法的报告、预防和控制方法、新的检测方法和设备、书籍评论及致编辑的信件。主题范围从艾滋病等相关领域的应用流行病学到疫苗开发的分子生物学。该杂志吸引了关注热带地区和发展中国家健康问题的流行病学家、寄生虫学家、病毒学家、临床医生、昆虫学家和公共卫生官员，以及新出现的传染病研究者。主要资助机构包括活跃于公共卫生领域的慈善机构和政府机构，以及世界各地的医学和科学图书馆，均购买该期刊。每年出版两期或更多关于特别感兴趣主题的增刊，这些增刊代表了对热带病专家关注的问题和发展中国家健康问题的全面和多学科讨论。

Category	Quartile
医学	4
医学, 热带医学	3
医学, 公共卫生、环境卫生与职业卫生	4

Infectomics of Chikungunya Virus: Roles Played by Host Factors

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Journal Info

Category	Quartile
TROPICAL MEDICINE	2