Induced hypothermia is an acknowledged useful therapy for treating conditions that lead to cell and tissue damage caused by ischemia, including traumatic brain injury, stroke, and cardiac arrest. An accumulating body of clinical evidence, together with several decades of research, has documented that the efficacy of hypothermia is dependent on achieving a reduced temperature in the target tissue before or soon following the ischemia-precipitating event. The temperature must be lowered to within a rather small range of values to effect therapeutic benefit without introducing collateral problems. Rewarming must be much slower than cooling. Many different methods and devices have been used for cooling, with mixed results. There are existing opportunities for bioengineers to improve our understanding of the mechanisms of hypothermia and to develop more effective methods of cooling the brain following trauma.

Kenneth R. Diller

Liang Zhu

Annual Review of Biomedical Engineering

自 1999 年出版的《生物医学工程年度回顾》涵盖了生物医学工程广泛领域的重大发展，包括生物力学、生物材料、计算基因组学和蛋白质组学、组织工程、生物监测、医疗保健工程、药物输送、生物电工程、生化工程和生物医学成像主题。

The Annual Review of Biomedical Engineering, published since 1999, covers significant developments across a wide range of topics in biomedical engineering, including biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biosensing, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging.

《Annual Review of Biomedical Engineering》自1999年出版，涵盖了生物医学工程领域的多个重要主题，包括生物力学、生物材料、计算基因组学与蛋白质组学、组织工程、生物监测、医疗工程、药物输送、生物电工程、生化工程以及生物医学成像等。

Hypothermia Therapy for Brain Injury

There are existing opportunities for bioengineers to improve the understanding of the mechanisms of hypothermia and to develop more effective methods of cooling the brain following trauma.

Category	Quartile
工程技术	1
工程技术, 工程生物医学	1

Hypothermia Therapy for Brain Injury

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Category	Quartile
ENGINEERING, BIOMEDICAL	1