Construction of multifunctional nanocomposites as theranostic platforms has received considerable biomedical attention. In this study, a triple-functional theranostic agent based on the cointegration of gold nanorods (Au NRs) and superparamagnetic iron oxide (Fe3O4) into polypyrrole was developed. Such a theranostic agent (referred to as Au/PPY@Fe3O4) not only exhibits strong magnetic property and high near-infrared (NIR) optical absorbance but also produces high contrast for magnetic resonance (MR) and X-ray computed tomography (CT) imaging. Importantly, under the irradiation of the NIR 808 nm laser at the power density of 2 W/cm2 for 10 min, the temperature of the solution containing Au/PPY@Fe3O4 (1.4 mg/mL) increased by about 35 °C. Cell viability assay showed that these nanocomposites had low cytotoxicity. Furthermore, an in vitro photothermal treatment test demonstrates that the cancer cells can be efficiently killed by the photothermal effects of the Au/PPY@Fe3O4 nanocomposites. In summary, this study demonstrates that the highly versatile multifunctional Au/PPY@Fe3O4 nanocomposites have great potential in simultaneous multimodal imaging-guided cancer theranostic applications.

Wei Feng

Xiaojun Zhou

Wei Nie

Liang Chen

Kexin Qiu

Yanzhong Zhang

Chuanglong He

ACS Applied Materials & Interfaces

ACS APPLIED MATERIALS & INTERFACES 是一本面向化学家、工程师、物理学家和生物学家的跨学科社区的新出版物，重点关注如何开发新发现的材料和界面过程并将其用于特定应用。该杂志除了发表致力于推进应用材料研究的评论和论坛外，还发表来自学术界和工业界研究人员的完整文章和信件。

ACS Applied Materials and Interfaces is an interdisciplinary journal aimed at chemists, engineers, physicists, and biologists, focusing on the development of newly discovered materials and interface processes for specific applications. The journal publishes not only reviews and forums that advance applied materials research but also full articles and letters from researchers in academia and industry.

《ACS Applied Materials and Interfaces》是一本面向化学家、工程师、物理学家和生物学家的跨学科期刊，专注于新材料和界面过程的开发及其特定应用。该杂志不仅发表推动应用材料研究的评论和论坛，还刊登来自学术界和工业界研究人员的完整文章和信件。

ACS Applied Materials and Interfaces

Au/Polypyrrole@Fe3O4Nanocomposites for MR/CT Dual-Modal Imaging Guided-Photothermal Therapy: Anin VitroStudy

It is demonstrated that the highly versatile multifunctional Au/PPY@Fe3O4 nanocomposites have great potential in simultaneous multimodal imaging-guided cancer theranostic applications.

Category	Quartile
材料科学	2
材料科学, 材料科学综合	2
材料科学, 纳米科技	2

Au/Polypyrrole@Fe₃O₄Nanocomposites for MR/CT Dual-Modal Imaging Guided-Photothermal Therapy: Anin VitroStudy

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Journal Info

Category	Quartile
NANOSCIENCE & NANOTECHNOLOGY	1