Cardiac arrest (CA) is a critical public health issue affecting more than half a million Americans annually. The main determinant of outcome post-CA is hypoxic–ischemic brain injury (HIBI), and temperature control is currently the only evidence-based, guideline-recommended intervention targeting secondary brain injury. Temperature control is a key component of a post-CA care bundle; however, conflicting evidence challenges its wide implementation across the vastly heterogeneous population of CA survivors. Here, we critically appraise the available literature on temperature control in HIBI, detail how the evidence has been integrated into clinical practice, and highlight the complications associated with its use and the timing of neuroprognostication after CA. Future clinical trials evaluating different temperature targets, rates of rewarming, duration of cooling, and identifying which patient phenotype benefits from different temperature control methods are needed to address these prevailing knowledge gaps.

Samantha Fernandez Hernandez

Brooke Barlow

Vera Pertsovskaya

Carolina B. Maciel

Advances in Therapy

ADVANCES IN THERAPY 是一本国际、同行评审、快速出版（2 周内同行评审，接受后 3-4 周出版）期刊，致力于出版高质量的临床（所有阶段）、观察性、真实世界和围绕所有治疗领域的治疗和干预措施（包括设备）的发现、开发和使用进行健康结果研究。还鼓励与诊断和诊断、药物经济学、公共卫生、流行病学、生活质量以及患者护理、管理和教育相关的研究。该杂志吸引了广大医疗保健专业人士的兴趣，并发表原创研究、评论、通讯和信件。该杂志由全球读者阅读，并接收来自世界各地的投稿。 ADVANCES IN THERAPY 将考虑所有科学合理的研究，无论是正面的、证实性的还是负面的数据。无论提交的内容是否与国际和/或特定国家的受众有关，都欢迎提交，这在研究人员试图针对更具体的患者群体时至关重要。这种包容性的方法使期刊能够协助传播所有科学和道德上合理的研究。

Advances in Therapy is an international, peer-reviewed, rapid publication journal dedicated to publishing high-quality clinical research (at all stages), observational studies, real-world evidence, and health outcomes research related to interventions (including devices) across all therapeutic areas. The journal encourages research related to diagnostics, pharmacoeconomics, public health, epidemiology, quality of life, as well as patient care, management, and education. It attracts a wide audience of healthcare professionals and publishes original research, reviews, communications, and letters. The journal has a global readership and accepts submissions from around the world. Advances in Therapy considers all scientifically valid research, whether positive, confirmatory, or negative data. Submissions are welcome regardless of their relevance to international and/or specific national audiences, which is crucial when researchers aim to target more specific patient populations. This inclusive approach allows the journal to assist in disseminating all scientifically and ethically sound research.

《Advances in Therapy》是一本国际同行评审的快速出版期刊，致力于发表高质量的临床研究（涵盖所有阶段）、观察性研究、真实世界研究以及与所有治疗领域相关的干预措施（包括设备）的健康结果研究。期刊鼓励与诊断、药物经济学、公共卫生、流行病学、生活质量以及患者护理、管理和教育相关的研究。该杂志吸引了广泛的医疗保健专业人士的关注，发表原创研究、评论、通讯和信件。它的读者遍布全球，欢迎来自世界各地的投稿。《Advances in Therapy》将考虑所有科学合理的研究，无论是正面、证实性还是负面数据。无论提交的内容是否与国际或特定国家的受众相关，均欢迎投稿，这在研究者针对更具体的患者群体时尤为重要。这种包容性的方法使期刊能够协助传播所有科学和伦理上合理的研究。

Temperature Control After Cardiac Arrest: A Narrative Review

This work critically appraise the available literature on temperature control in HIBI, detail how the evidence has been integrated into clinical practice, and highlight the complications associated with its use and the timing of neuroprognostication after CA.

Category	Quartile
医学	3
医学, 医学研究与实验	3
医学, 药学	3

Temperature Control After Cardiac Arrest: A Narrative Review

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	2