The thyroid hormone (TH) plays a significant role in diverse processes related to growth, development, differentiation, and metabolism. TH signaling modulates energy expenditure through both central and peripheral pathways. At the cellular level, the TH exerts its effects after concerted mechanisms facilitate binding to the TH receptor. In the hypothalamus, signals from a range of metabolic pathways, including appetite, temperature, afferent stimuli via the autonomic nervous system, availability of energy substrates, hormones, and other biologically active molecules, converge to maintain plasma TH at the appropriate level to preserve energy homeostasis. At the tissue level, TH actions on metabolism are controlled by transmembrane transporters, deiodinases, and TH receptors. In the modern environment, humans are susceptible to an energy surplus, which has resulted in an obesity epidemic and, thus, understanding the contribution of the TH to cellular and organism metabolism is increasingly relevant.

Elizabeth A. McAninch

Antonio C. Bianco

Annals of the New York Academy of Sciences

代表纽约科学院出版的《纽约科学院年鉴》为当前科学兴趣的研究提供了多学科视角，对更广泛的科学界和整个社会具有深远的影响。在新兴发展提供新见解的承诺之际，每期特刊都汇集了该研究领域关键贡献者的最佳思想。个别主题的年鉴特刊通过提供一个中立的讨论论坛——在许多机构和领域内和跨领域，激发了思考科学的新方式。

The Annals of the New York Academy of Sciences is a journal published by the New York Academy of Sciences that offers a multidisciplinary perspective on current scientific research interests, having a profound impact on the broader scientific community and society as a whole. Each special issue gathers the best thoughts from key contributors in the field, committed to providing new insights into emerging developments. The annual special issues on individual topics serve as a neutral discussion forum, stimulating new ways of thinking about science across various institutions and disciplines.

《Annals of the New York Academy of Sciences》是由纽约科学院出版的期刊，提供了多学科视角，关注当前科学研究的热点问题，对科学界和社会产生了深远的影响。每期特刊汇集了该研究领域内关键贡献者的最佳思想，承诺为新兴发展提供新的见解。个别主题的年鉴特刊通过提供一个中立的讨论论坛，激发了跨领域的科学思考，促进了不同机构和领域之间的交流。

Thyroid hormone signaling in energy homeostasis and energy metabolism

The thyroid hormone plays a significant role in diverse processes related to growth, development, differentiation, and metabolism and understanding the contribution of the TH to cellular and organism metabolism is increasingly relevant.

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综合性期刊	3
综合性期刊, 综合性期刊	3

Thyroid hormone signaling in energy homeostasis and energy metabolism

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Category	Quartile
MULTIDISCIPLINARY SCIENCES	1