Secondary hyperparathyroidism occurs early in the course of chronic renal failure. Early in the course, a deficit of calcitriol and an abnormality in the calcium sensor receptor may be the important factors; later, with advanced renal failure, hyperphosphatemia becomes an additional important pathogenic factor. Important clinical problems in dialysis patients are as follows: (1) hyperphosphatemia, which contributes to high morbidity and mortality of dialysis patients (a clinical approach to maintaining a normal serum phosphorus is essential and is discussed in this review); (2) a high calcium X phosphorus product leading to coronary artery calcifications (factors leading to calcifications are also discussed); and (3) calciphylaxis, which has been observed with increasing frequency in these patients (an increase in the total calcium load may be the most important pathogenic factor leading to this syndrome). Therapeutic considerations regarding the use of new vitamin D analogues devoid of a hypercalcemic and/or a hyperphosphatemic effect are also mentioned.

Francisco Llach

Francisco Velasquez Forero

American Journal of Kidney Diseases

美国肾脏病杂志 (AJKD) 是美国国家肾脏基金会的官方期刊，在全球范围内被公认为临床肾脏病学内容的领导者。每个月 AJKD 都会发布原始调查报告，描述与肾脏疾病、高血压、透析疗法和肾移植相关的最新发现。除了对所有 AJKD 内容进行严格的同行评审外，原始调查还要接受例行的统计审查，并遵循一致的结构化格式。每一期的病例报告都揭示了新的疾病和潜在的治疗策略。

The American Journal of Kidney Diseases (AJKD) is the official journal of the National Kidney Foundation and is recognized globally as a leader in the field of clinical nephrology. Each month, AJKD publishes original research reports that describe the latest findings related to kidney disease, hypertension, dialysis, and kidney transplantation. All content in AJKD undergoes rigorous peer review, and original investigations are subject to routine statistical review and follow a consistent structured format. Each issue's case reports reveal new diseases and potential treatment strategies.

《美国肾脏病杂志》（American Journal of Kidney Diseases，AJKD）是美国国家肾脏基金会的官方期刊，全球公认的临床肾脏病学领域的领导者。每月，AJKD 发布原始研究报告，介绍与肾脏疾病、高血压、透析和肾移植相关的最新发现。所有AJKD的内容都经过严格的同行评审，原始研究还需接受例行的统计审查，并遵循一致的结构化格式。此外，每期的病例报告揭示了新的疾病和潜在的治疗策略。

Secondary hyperparathyroidism in chronic renal failure: Pathogenic and clinical aspects

Therapeutic considerations regarding the use of new vitamin D analogues devoid of a hypercalcemic and/or a hyperphosphatemic effect are also mentioned.

Category	Quartile
医学	1
医学, 泌尿学与肾脏学	1

Secondary hyperparathyroidism in chronic renal failure: Pathogenic and clinical aspects

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Journal Info

Category	Quartile
UROLOGY & NEPHROLOGY	1