Accurately characterizing bone properties using quantitative ultrasound remains a significant challenge due to the dispersive nature of guided waves, limited observations, irregularity of bone structure, and heterogeneity of bone tissues. In this paper, an inversion technique is proposed that combines weighted mean absolute criteria and the simulated annealing algorithm to extract the thicknesses and elastic properties of a bilayer bone model. By utilizing the L1 norm with an appropriate weighting parameter, this method effectively reduces the influence of outliers and noises commonly encountered in ultrasonic data, leading to more accurate estimation. This paper also introduces an asymptotic scheme to significantly reduce the search domain, improving the speed and precision of the inversion process. This approach employs a spectral collocation method as a forward modeling technique to simulate guided waves in a bone plate coated by a soft tissue layer. This paper validates the inversion using simulated and ex vivo data and demonstrates its ability to estimate features of cortical bone and soft tissue with high accuracy. Results are presented for the isotropic model. These findings hold great promise for the accurate characterization of bone properties using quantitative ultrasound, with potential applications in clinical diagnosis and treatment of bone-related diseases and injuries.

Ductho Le

Mauricio D. Sacchi

Edmond Lou

Lawrence H. Le

The Journal of the Acoustical Society of America

自 1929 年以来，《美国声学学会杂志》一直是广泛的跨学科声音研究中理论和实验研究成果的主要来源。学科覆盖范围包括：线性和非线性声学；气动声学、水下声音和声学海洋学；超声波和量子声学；建筑和结构声学和振动；语音、音乐和噪音；听力心理学和生理学；工程声学、转换；生物声学，动物生物声学。

Since 1929, the Journal of the Acoustical Society of America has been a major source of theoretical and experimental research findings in the broad field of interdisciplinary sound studies. The journal covers a wide range of subjects, including linear and nonlinear acoustics; aeroacoustics, underwater sound, and acoustic oceanography; ultrasonics and quantum acoustics; architectural and structural acoustics and vibrations; speech, music, and noise; auditory psychology and physiology; engineering acoustics and transduction; and bioacoustics, including animal bioacoustics.

自1929年以来，《Journal of the Acoustical Society of America》一直是跨学科声音研究中理论与实验研究成果的重要来源。该期刊涵盖的学科包括：线性与非线性声学；气动声学、水下声学及声学海洋学；超声波与量子声学；建筑声学、结构声学与振动；语音、音乐与噪音；听力心理学与生理学；工程声学与转换；生物声学及动物生物声学。

Category	Quartile
物理与天体物理	2
物理与天体物理, 声学	3
物理与天体物理, 听力学与言语病理学	3

Robust guided wave inversion for estimating bone thickness and elasticity

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Journal Info

Category	Quartile
AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY	1