Ossification of the posterior longitudinal ligament (OPLL) is a multi-factorial disease involving an ectopic bone formation of spinal ligaments. It affects 0.8-3.0% aging Asian and 0.1-1.7% aging European Caucasian. The ossified ligament compresses nerve roots in the spinal cord and causes serious neurological problems such as myelopathy and radiculopathy. Research in understanding pathogenesis of OPLL over the past several decades have revealed many genetic and non-genetic factors contributing to the development and progress of OPLL. The characterizations of aberrant signaling of bone morphogenetic protein (BMP) and mitogen-activated protein kinases (MAPK), and the pathological phenotypes of OPLL-derived mesenchymal stem cells (MSCs) have provided new insights on the molecular mechanisms underlying OPLL. This paper reviews the recent progress in understanding the pathophysiology of OPLL and proposes future research directions on OPLL.

Liang Yan

Rui Gao

Yang Liu

Baorong He

Shemin Lv

Dingjun Hao

Aging and Disease

AGING & DISEASE (A&D) 是一本同行评议的开放获取在线期刊，旨在发表关于衰老生物学、年龄相关疾病的病理生理学以及影响老年人疾病的创新疗法等核心问题的新颖且具有高影响力的研究结果人口。感兴趣的疾病包括（但不限于）中风、阿尔茨海默病、帕金森病、癫痫、痴呆、抑郁症、心血管疾病、癌症、关节炎、白内障、骨质疏松症、糖尿病和高血压。动物模型和人类研究欢迎组织或细胞。

Aging and Disease (A&D) is a peer-reviewed open-access online journal dedicated to publishing novel and impactful research findings on core issues related to aging biology, the pathophysiology of age-related diseases, and innovative therapies affecting diseases in older adults. The diseases of interest include, but are not limited to, stroke, Alzheimer's disease, Parkinson's disease, epilepsy, dementia, depression, cardiovascular diseases, cancer, arthritis, cataracts, osteoporosis, diabetes, and hypertension. We welcome submissions of both animal models and human studies.

《Aging and Disease》是一本经过同行评审的开放获取在线期刊，旨在发表关于衰老生物学、年龄相关疾病的病理生理学以及影响老年人疾病的创新疗法等核心问题的新颖且具有高影响力的研究成果。我们关注的疾病包括（但不限于）中风、阿尔茨海默病、帕金森病、癫痫、痴呆、抑郁症、心血管疾病、癌症、关节炎、白内障、骨质疏松症、糖尿病和高血压。我们欢迎动物模型和人类研究的投稿。

The Pathogenesis of Ossification of the Posterior Longitudinal Ligament

The characterizations of aberrant signaling of bone morphogenetic protein (BMP) and mitogen-activated protein kinases (MAPK), and the pathological phenotypes of OPLL-derived mesenchymal stem cells (MSCs) have provided new insights on the molecular mechanisms underlying OPLL.

Category	Quartile
医学	2
医学, 老年医学	3

The Pathogenesis of Ossification of the Posterior Longitudinal Ligament

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Journal Info

Category	Quartile
GERIATRICS & GERONTOLOGY	1