Autism spectrum disorder (ASD) is characterized by deficits in social communication and interaction. Since its discovery as a major functional brain system, the default mode network (DMN) has been implicated in a number of psychiatric disorders, including ASD. Here we review converging multimodal evidence for DMN dysfunction in the context of specific components of social cognitive dysfunction in ASD: 'self-referential processing' - the ability to process social information relative to oneself and 'theory of mind' or 'mentalizing' - the ability to infer the mental states such as beliefs, intentions, and emotions of others. We show that altered functional and structural organization of the DMN, and its atypical developmental trajectory, are prominent neurobiological features of ASD. We integrate findings on atypical cytoarchitectonic organization and imbalance in excitatory-inhibitory circuits, which alter local and global brain signaling, to scrutinize putative mechanisms underlying DMN dysfunction in ASD. Our synthesis of the extant literature suggests that aberrancies in key nodes of the DMN and their dynamic functional interactions contribute to atypical integration of information about the self in relation to 'other', as well as impairments in the ability to flexibly attend to socially relevant stimuli. We conclude by highlighting open questions for future research.

Aarthi Padmanabhan

Charles J Lynch

Marie Schaer

Vinod Menon

Biological psychiatry. Cognitive neuroscience and neuroimaging

BIOLOGICAL PSYCHIATRY: COGNITIVE NEUROSCIENCE AND NEUROIMAGING 是生物精神病学协会的官方期刊，其目的是促进在研究思维、情绪或情绪障碍的性质、原因、机制和治疗领域的科学研究和教育的卓越成就。行为。根据这一使命，这本经过同行评审、快速出版的国际期刊专注于使用认知神经科学的工具和结构进行的研究，包括全方位的非侵入性神经影像学和人类颅外和颅内生理记录方法。它发表基础研究和临床研究，包括那些包含遗传数据、药理学挑战和计算建模方法的研究。该杂志发表原创研究的新结果，这些结果代表了对该领域的重要新领导或重大影响。还鼓励关注当前研究和兴趣主题的评论和评论。

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is the official journal of the Biological Psychiatry Association, aimed at promoting excellence in scientific research and education in the nature, causes, mechanisms, and treatments of thinking, emotion, or affective disorders. In line with this mission, this peer-reviewed, rapid publication international journal focuses on research conducted using tools and structures from cognitive neuroscience, including comprehensive non-invasive neuroimaging and human extracranial and intracranial physiological recording methods. It publishes both basic and clinical research, including studies that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal welcomes new findings from original research that represent significant innovations or substantial impacts in the field. We also encourage reviews and discussions on current research topics and areas of interest.

《Biological Psychiatry: Cognitive Neuroscience and Neuroimaging》是生物精神病学协会的官方期刊，旨在促进在思维、情绪及情绪障碍的性质、原因、机制和治疗领域的科学研究与教育。作为一本经过同行评审、快速出版的国际期刊，本刊专注于利用认知神经科学的工具和方法进行的研究，包括全面的非侵入性神经影像学和人类颅外及颅内生理记录技术。期刊发表基础研究和临床研究，尤其是那些涉及遗传数据、药理学挑战和计算建模方法的研究。我们欢迎原创研究的新发现，这些发现对该领域具有重要的创新性或显著影响。同时，我们也鼓励对当前研究热点和主题的评论与讨论。

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Biol Psychiatry Cogn Neurosci Neuroimaging

The Default Mode Network in Autism.

It is suggested that aberrancies in key nodes of the DMN and their dynamic functional interactions contribute to atypical integration of information about the self in relation to 'other', as well as impairments in the ability to flexibly attend to socially relevant stimuli.

Category	Quartile
医学	2
医学, 神经科学	2

The Default Mode Network in Autism.

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