Chronic rhinosinusitis with nasal polyposis (CRSNP) and asthma are inflammatory lesions of the respiratory epithelium. This study was conducted to evaluate predictive factors of bronchial hyperresponsiveness (BHR) in patients with CRSNP.BHR was evaluated using a methacholine bronchoprovocation test (MBPT) in 122 consecutive patients newly diagnosed with CRSNP at Seoul National University Hospital from January 2004 to June 2006. The following parameters were analyzed and compared between the BHR and non-BHR groups: symptoms, atopic status, current smoking, disease severity of CRSNP based on the Lund-Mackay scoring system of sinus CT, and counts of eosinophils in the serum and nasal tissues.Thirty-five percent of the patients were found to have BHR, and BHR was found to occur more frequently in patients that were currently suffering from sneezing (P = 0.007). In addition, the mean eosinophil counts of the serum and nasal tissues were higher in the BHR group than in the non-BHR group (P = 0.001 for the serum, P = 0.045 for the nasal tissues), and the eosinophil counts of the serum correlated to those of the nasal tissues (r = 0.334, P = 0.013). The disease severity, as determined by the Lund-Mackay scoring system, was not different between the two groups (P > 0.05). The best cutoff serum eosinophil count for predicting BHR in CRSNP patients was determined to be 300 cells/microl (sensitivity 70%, specificity 70%).Taken together, these results indicate that moderate to severe sneezing and a serum eosinophil count > or = 300 cells/microl may be predictive factors for BHR in patients with CRSNP.

D. H. Han

S. W. Kim

S. H. Cho

D. Y. Kim

C. H. Lee

S. S. Kim

C. S. Rhee

Allergy

ALLERGY 的目的是推进、影响和交流过敏/免疫学学科的各个方面，包括教育、基础、转化和临床研究，并保持基础和临床过敏/免疫学之间的联系。ALLERGY 是一本国际期刊，其贡献者和读者来自所有国家。 ALLERGY 发表原创文章、评论、立场文件、指南、社论、新闻和评论、致编辑的信函和通信。文章的接受纯粹是基于科学价值和质量。

The purpose of Allergy: European Journal of Allergy and Clinical Immunology is to advance, influence, and communicate all aspects of the field of allergy and immunology, including education, basic research, translational research, and clinical studies, while maintaining a close connection between basic and clinical allergy/immunology. This is an international journal with contributors and readers from all countries. Allergy publishes original research articles, reviews, position papers, guidelines, editorials, news, letters to the editor, and communications. Acceptance of articles is solely based on their scientific value and quality.

《Allergy: European Journal of Allergy and Clinical Immunology》旨在推动、影响和交流过敏与免疫学领域的各个方面，包括教育、基础研究、转化研究和临床研究，并保持基础与临床过敏/免疫学之间的紧密联系。该期刊是一本国际性期刊，贡献者和读者来自世界各地。《Allergy》发表原创研究文章、评论、立场文件、指南、社论、新闻、读者来信及其他通讯。文章的接受完全基于其科学价值和质量。

Allergy: European Journal of Allergy and Clinical Immunology

Predictors of bronchial hyperresponsiveness in chronic rhinosinusitis with nasal polyp

This study was conducted to evaluate predictive factors of bronchial hyperresponsiveness (BHR) in patients with CRSNP and found that chronic rhinosinusitis with nasal polyposis and asthma are inflammatory lesions of the respiratory epithelium.

Category	Quartile
医学	1
医学, 免疫学	1
医学, 过敏	2

Predictors of bronchial hyperresponsiveness in chronic rhinosinusitis with nasal polyp

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