Abstract The TAM receptor tyrosine kinase family member AXL plays critical roles in tissue homeostasis, survival, chemoresistance, and motility. This study investigates the receptor expression in six AML cell lines and bone marrow myeloblasts from 25 patients with myeloid neoplasms. We found that AXL expression was generally absent or very low in AML myeloblasts. These findings suggest that the efficacy of AXL inhibitors may not depend on AXL positivity but rather on alternative therapeutic mechanisms, such as inducing significant immune responses.

Pia Aehnlich

Katharina Leuchte

Claudia Schöllkopf

Sara Fresnillo Salo

Tina J. Seremet

Estrid Høgdall

Özcan Met

Kirsten Grønbaek

Per thor Straten

Biomarker Research

BIOMARKER RESEARCH 是一本开放获取、同行评审的期刊，涵盖了生物标志物研究的所有方面。生物标志物研究旨在发表与所有生物医学学科的生物标志物研究相关的原始发现、新概念、评论和评论。生物标志物的研究随着个性化医疗和个人健康的发展而迅速发展。在药物发现/开发以及疾病诊断、治疗、预后和预防中，生物标志物的识别和验证在基因组时代发挥着至关重要的作用。凭借从提交到出版的快速周转时间以及读者的在线反馈，BIOMARKER RESEARCH 致力于快速传播新发现和新知识。

Biomarker Research is an open access, peer-reviewed journal that covers all aspects of biomarker research. The journal aims to publish original findings, new concepts, reviews, and commentaries related to biomarker studies across all biomedical disciplines. The research on biomarkers has rapidly evolved alongside the advancements in personalized medicine and individual health. The identification and validation of biomarkers play a crucial role in drug discovery and development, as well as in disease diagnosis, treatment, prognosis, and prevention in the genomic era. Biomarker Research is committed to the rapid dissemination of new discoveries and knowledge, offering a quick turnaround time from submission to publication and encouraging online feedback from readers.

《Biomarker Research》是一本开放获取、同行评审的期刊，涵盖生物标志物研究的各个方面。该期刊旨在发表与所有生物医学学科相关的生物标志物研究的原创发现、新概念、评论和综述。随着个性化医疗和个人健康的快速发展，生物标志物的研究也在不断进步。在药物发现与开发、疾病诊断、治疗、预后和预防中，生物标志物的识别与验证在基因组时代扮演着至关重要的角色。《Biomarker Research》致力于快速传播新发现和新知识，提供从提交到出版的快速周转时间，并鼓励读者在线反馈。

Category	Quartile
医学	2
医学, 医学研究与实验	2
医学, 肿瘤学	2

AXL in myeloid malignancies – an elusive target?

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