Abstract The increased demand for the synthesis of Csp 3 enriched motifs and the urgency of discovering new drugs requires the development of more efficient technologies and synthetic tools to accelerate drug discovery processes. Herein, we report a fully automated strategy for the addition of Csp 3 enriched building blocks onto olefins via Giese addition to forge Csp 3 −Csp 3 bonds. The developed fully automated protocol allowed the in‐situ conversion of aldehydes (non‐redox‐active species) to electroactive imidazolidines and their use as precursors of C‐centered radicals under photoredox catalyzed conditions for the synthesis of building blocks and bioactive compound libraries by synthesizing sp 3 ‐enriched compounds.

Adrián Luguera Ruiz

Brenda Pijper

Maria Lourdes Linares

Santiago Cañellas

Stefano Protti

Maurizio Fagnoni

Jesús Alcázar

Chemistry - Methods

Chemistry-Methods

Automated One‐pot Library Synthesis with Aldehydes as Radical Precursors

醛作为自由基前体的自动化一锅法文库合成

Automated One‐pot Library Synthesis with Aldehydes as Radical Precursors

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	1