Methanol is a widely used industrial and household alcohol that poses significant health risks upon exposure. Despite its extensive use, methanol poisoning remains a critical public health concern globally, often resulting from accidental or intentional ingestion and outbreaks linked to contaminated beverages. Methanol toxicity stems from its metabolic conversion to formaldehyde and formic acid, leading to severe metabolic acidosis and multiorgan damage, including profound CNS effects and visual impairments. Epidemiological data underscore the widespread impact of methanol poisoning, with alarming case fatality rates reported in various countries. Comprehensive prevention and effective management strategies are urgently needed to address the significant morbidity and mortality associated with methanol poisoning. The clinical manifestations of methanol toxicity vary between adult and pediatric populations and between acute and chronic exposure. Adults typically present with gastrointestinal and neurological symptoms, whereas pediatric patients often exhibit more severe outcomes due to differences in metabolism and body weight. The diagnosis of methanol poisoning involves a combination of clinical evaluation, laboratory testing, and advanced diagnostic techniques. The identification of metabolic acidosis, elevated anion and osmolal gaps, and confirmation through methanol and formate levels are critical for accurate diagnosis. Timely intervention is crucial, and the management of methanol poisoning includes securing the airway, breathing, and circulation; addressing metabolic acidosis with sodium bicarbonate; administering antidotes such as fomepizole or ethanol; and administering hemodialysis, which plays a pivotal role in eliminating methanol and its toxic metabolites, especially in severe cases. The complexity of methanol poisoning necessitates a comprehensive approach encompassing early recognition, prompt intervention, and coordinated care among healthcare providers. Increased awareness, effective prevention strategies, and timely treatment protocols are essential to mitigate severe health consequences and improve patient survival and recovery.

Mohammed Alrashed

Norah S. Aldeghaither

Shatha Y. Almutairi

Meshari Almutairi

Abdulrhman Alghamdi

Tariq Alqahtani

Ghada H. Almojathel

Nada A. Alnassar

Sultan M. Alghadeer

Abdulmajeed Alshehri

Mohammed Alnuhait

Omar A. Almohammed

Toxics

该杂志接受的论文描述了进一步了解化学品和材料在人类和自然环境中的暴露、影响和风险以及评估和/或管理化学品和材料的毒理学和生态毒理学风险的方法的工作。该杂志涵盖范围广泛的有毒物质，包括金属、杀虫剂、药物、杀菌剂、纳米材料和聚合物，例如微塑料和中塑料。 TOXICS 接受的论文涵盖：化学品和材料在不同系统（例如，食物、空气、水、土壤）中的发生、运输和归宿；人类和环境暴露于有毒化学品和材料以及建模和实验方法表征例如水、空气、土壤、食品和消费品中的暴露；化学品和材料在广泛的系统中的吸收、代谢和影响，包括体外毒理学分析、水生和陆地生物和生态系统、模型哺乳动物系统和人类；评估化学品和材料对人类和环境的风险的方法；消除或减少人类和环境暴露于有毒化学品和材料的方法。

The journal "Toxics" publishes papers aimed at advancing the understanding of the exposure, effects, and risks of chemicals and materials in human and natural environments, as well as methods for assessing and managing the toxicological and ecotoxicological risks associated with these chemicals and materials. The journal covers a wide range of toxic substances, including metals, pesticides, pharmaceuticals, biocides, nanomaterials, and polymers such as microplastics and mesoplastics. Topics accepted by "Toxics" include: the occurrence, transport, and fate of chemicals and materials in various systems (e.g., food, air, water, soil); human and environmental exposure to toxic chemicals and materials, characterized through modeling and experimental methods in media such as water, air, soil, food, and consumer products; the absorption, metabolism, and effects of chemicals and materials in diverse systems, including in vitro toxicological analyses, aquatic and terrestrial organisms and ecosystems, model mammalian systems, and humans; methods for assessing the risks of chemicals and materials to human health and the environment; and approaches to eliminate or reduce human and environmental exposure to toxic chemicals and materials.

《Toxics》期刊接受的论文旨在深入了解化学品和材料在人类及自然环境中的暴露、影响和风险，以及评估和管理这些化学品和材料的毒理学和生态毒理学风险的方法。该期刊涵盖广泛的有毒物质，包括金属、杀虫剂、药物、杀菌剂、纳米材料和聚合物（如微塑料和中塑料）。《Toxics》接受的论文主题包括：化学品和材料在不同系统（如食物、空气、水、土壤）中的出现、迁移和归宿；人类和环境对有毒化学品和材料的暴露，以及通过建模和实验方法对水、空气、土壤、食品和消费品中的暴露进行表征；化学品和材料在多种系统中的吸收、代谢和影响，包括体外毒理学分析、水生和陆地生物及生态系统、模型哺乳动物系统和人类；评估化学品和材料对人类和环境风险的方法；以及消除或减少人类和环境对有毒化学品和材料的暴露的方法。

Category	Quartile
环境科学与生态学	3
环境科学与生态学, 环境科学	3
环境科学与生态学, 毒理学	3

The Perils of Methanol Exposure: Insights into Toxicity and Clinical Management

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