Piperine is an amide alkaloid isolated from the black pepper plant. This study examined the pain‑relieving activity of piperine against paclitaxel (PTX)‑induced neuropathy. Male mice were divided into 6 groups: Sham‑operated group (remained intact), PTX group (PTX‑treated mice receiving normal saline), PTX+ piperine 10, 25, and 50 mg/kg groups (PTX‑treated mice receiving piperine) and positive control group (PTX‑treated mice receiving imipramine 10 mg/kg). Neuropathic pain was induced by PTX 2 mg/kg/day on days 1, 3, 5 and 7. On day 7, behavioral tests were conducted and serum levels of interleukin‑6 (IL‑6), tumor necrosis factor‑alpha (TNF‑α), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were assayed. PTX produced significant thermal hyperalgesia compared to the sham group. Piperine at all doses alleviated neuropathic pain, and significantly decreased IL‑6, TNF‑α, and MDA, but induced CAT and SOD activities compared to the control group. Piperine could confer beneficial effects against neuropathic pain, at least partially, via reduction of inflammatory and oxidative stress markers.

Toktam Sahranavard

Vahideh Ghorani

Fatemeh Forouzanfar

Samaneh Sadat Asadi Kakhki

Ebrahim Nikfar Dastaki

Ebrahim Golmakani

Ramin Rezaee

Acta Neurobiologiae Experimentalis

ACTA NEUROBIOLOGIAE EXPERIMENTALIS (ISSN: 0065-1400 (PRINT), EISSN: 1689-0035) 涵盖神经科学的各个方面，从神经系统的分子和细胞神经生物学，到细胞和系统电生理学、脑成像、功能和比较神经解剖学、发育以及神经系统、行为和神经心理学向大脑衰老和病理学的演变，包括神经信息学和建模。

Acta Neurobiologiae Experimentalis covers various aspects of neuroscience, ranging from molecular and cellular neurobiology of the nervous system to cellular and systems electrophysiology, brain imaging, functional and comparative neuroanatomy, development, as well as the evolution of behavior and neuropsychology related to brain aging and pathology, including neuroinformatics and modeling.

《Acta Neurobiologiae Experimentalis》涵盖神经科学的各个方面，包括神经系统的分子和细胞神经生物学、细胞和系统电生理学、脑成像、功能和比较神经解剖学、发育、神经系统的行为和神经心理学，以及大脑衰老和病理学的演变，涉及神经信息学和建模等领域。

Category	Quartile
医学	4
医学, 神经科学	4

Piperine relieves neuropathic pain induced by paclitaxel in mice

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