Abstract INTRODUCTION Limited research has extensively analyzed neurodegenerative disease–related protein deposition patterns in the hippocampus. METHODS This study examined the distribution of proteins in hippocampal subregions across major neurodegenerative diseases and explored their relation to each other. The area density of phosphorylated tau (p‐tau), amyloid beta (Aβ), α‐synuclein, and phosphorylated TDP‐43 protein deposits together with pyramidal cell density in each hippocampal subregion, including CA1‐4, prosubiculum (ProS), and subiculum was assessed in 166 cases encompassing various neurodegenerative diseases. RESULTS Alzheimer's disease‐associated p‐tau predominated in ProS, Aβ in the CA1, and Lewy body–related α‐synuclein in the CA2. The area density of protein deposits increased with the pathological stage until a peak, then decreased in cases with high pathology stages along with pyramidal cell density. Comorbid protein pathology influenced protein deposition patterns. DISCUSSION This comprehensive evaluation reveals characteristic neurodegenerative disease–related protein accumulation patterns in hippocampal subregions modified by co‐pathologies. Highlights Alzheimer's disease–related phosphorylated tau predominates in the prosubiculum. Amyloid beta predominates in the CA1 and Lewy body–related α‐synuclein in the CA2. The area density of protein deposition increases with the disease stage up to a peak. In the high pathology stage, protein deposition and pyramidal cell density decreases. Comorbid protein pathology affects the pattern of protein accumulation.

Koji Yoshida

Shelley L. Forrest

Shojiro Ichimata

Hidetomo Tanaka

Tomoya Kon

Gabor G. Kovacs

Alzheimer s & Dementia

阿尔茨海默病与痴呆症：阿尔茨海默病协会杂志的使命是弥合广泛的实验室到床边调查的知识差距。该杂志发表以下研究成果：行为学、生物化学、遗传学、分子生物学、药理学、生理学、蛋白质化学、神经学、神经病理学、精神病学、老年病学、神经心理学、流行病学、社会学、卫生服务研究、卫生经济学、政治学和公共政策。内容强调跨学科调查、综合/翻译文章，涉及：病因、风险因素、早期发现、疾病改变干预、痴呆症预防和新技术在卫生服务中的应用。

Alzheimer's and Dementia is the official journal of the Alzheimer's Association, aimed at bridging the knowledge gap between laboratory research and clinical application. The journal publishes research across various fields, including behavioral science, biochemistry, genetics, molecular biology, pharmacology, physiology, protein chemistry, neurology, neuropathology, psychiatry, geriatrics, neuropsychology, epidemiology, sociology, health services research, health economics, political science, and public policy. The content emphasizes interdisciplinary investigations, particularly comprehensive and translational articles, addressing etiology, risk factors, early detection, disease-modifying interventions, dementia prevention, and the application of new technologies in health services.

《Alzheimer's and Dementia》是阿尔茨海默病协会的官方期刊，旨在弥合实验室研究与临床应用之间的知识差距。该期刊发表的研究涵盖多个领域，包括行为学、生物化学、遗传学、分子生物学、药理学、生理学、蛋白质化学、神经学、神经病理学、精神病学、老年病学、神经心理学、流行病学、社会学、卫生服务研究、卫生经济学、政治学和公共政策。内容强调跨学科的研究，特别是综合性和翻译性文章，涉及病因、风险因素、早期发现、疾病干预、痴呆症预防以及新技术在卫生服务中的应用。

Category	Quartile
医学	1
医学, 临床神经病学	1

Co‐pathologies modify hippocampal protein accumulation patterns in neurodegenerative diseases

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Journal Info

Category	Quartile
CLINICAL NEUROLOGY	1