Abstract Cisplatin is widely used in clinical cancer treatment; however, its application is often hindered by severe side effects, particularly inherent or acquired resistance of target cells. To address these challenges, an effective strategy is to modify the metal core of the complex and introduce alternative coordination modes or valence states, leading to the development of a series of metal complexes, such as platinum (IV) prodrugs and cyclometalated complexes. Recent advances in nanotechnology have facilitated the development of multifunctional nanomaterials that can selectively deliver drugs to tumor cells, thereby overcoming the pharmacological limitations of metal‐based drugs. This review first explores the self‐assembly of metal complexes into spherical, linear, and irregular nanoparticles in the context of biomedical applications. The mechanisms underlying the self‐assembly of metal complexes into nanoparticles are subsequently analyzed, followed by a discussion of their applications in biomedical fields, including detection, imaging, and antitumor research.

Wenting Wang

Yang Xu

Yuqi Tang

Quan Li

Advanced Materials

30 多年来，ADVANCED MATERIALS 每周都会为您带来材料科学的最新进展。阅读功能材料化学和物理前沿的精心挑选的高质量评论、进展报告、通讯和研究新闻。 ADVANCED MATERIALS 的影响因子为 25.809（2018 期刊影响因子，期刊引文报告（CLARIVATE ANALYTICS，2019））。 ADVANCED MATERIALS 成功的关键之一是其明显的跨学科性。

Since its inception, the journal Advanced Materials has been delivering the latest advancements in materials science for over 30 years. The content includes cutting-edge reviews, progress reports, communications, and research news in the fields of functional materials chemistry and physics. According to the 2018 Journal Impact Factor (Journal Citation Reports, Clarivate Analytics, 2019), Advanced Materials has an impact factor of 25.809. One of the keys to the journal's success is its remarkable interdisciplinary nature.

《Advanced Materials》期刊自创刊以来，已持续30多年为读者提供材料科学领域的最新研究进展。期刊内容包括功能材料的化学和物理前沿，涵盖高质量的评论、进展报告、通讯和研究新闻。根据2018年的期刊影响因子（来自期刊引文报告，CLARIVATE ANALYTICS，2019），《Advanced Materials》的影响因子为25.809。该期刊成功的关键之一在于其显著的跨学科特性。

Category	Quartile
材料科学	1
材料科学, 化学综合	1
材料科学, 物理化学	1
材料科学, 材料科学综合	1
材料科学, 纳米科技	1
材料科学, 物理应用	1
材料科学, 物理凝聚态物理	1

Self‐Assembled Metal Complexes in Biomedical Research

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Journal Info

Category	Quartile
PHYSICS, CONDENSED MATTER	1