Dynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivatives. An ever‐increasing number of publications report the use of DCC on biologically relevant target proteins. This minireview complements previous reviews by focusing on the experimental protocol and giving detailed examples of essential steps and factors that need to be considered, such as protein stability, buffer composition and cosolvents.

Alwin M. Hartman

Robin M. Gierse

Anna K. H. Hirsch

European Journal of Organic Chemistry

Annalen der Pharmacie

Protein‐Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol

This minireview complements previous reviews by focusing on the experimental protocol and giving detailed examples of essential steps and factors that need to be considered, such as protein stability, buffer composition and cosolvents.

Category	Quartile
化学	3
化学, 有机化学	3

Protein‐Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol

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Journal Info

Category	Quartile
CHEMISTRY, ORGANIC	2