Hepatitis B virus (HBV) is a major human pathogen, and chronic hepatitis can lead to cirrhosis and malignant hepatocellular carcinoma. While HBV vaccine and treatment are available, it has remained a challenge to completely eradicate the virus from patients. Current therapy using either interferon or polymerase inhibitors cannot cure HBV with a high efficacy. Lifelong therapy is needed to suppress HBV in patients who achieve no seroconversion. Here, we review recent exciting advances of new strategies, including the inhibition of viral entry, the destruction or silencing of HBV covalently closed circular DNA (cccDNA), and breaking immune tolerance. Combinations of different therapeutic strategies could improve the cure rate of viral persistence in chronic hepatitis B.

Chiaho Shih

Shu-Fan Chou

Ching-Chun Yang

Jyun-Yuan Huang

Gansukh Choijilsuren

Ren-Shiang Jhou

Trends in microbiology

TRENDS IN MICROBIOLOGY 为讨论微生物学的各个方面提供了一个多学科论坛：从细胞生物学和免疫学到遗传学和进化，涵盖病毒学、细菌学、原生动物学和真菌学。微生物学是目前发展最快的学科之一。生命科学，也得益于近年来的技术发展。对小基因组进行完整测序的相对容易和快速开始对原核生物的所有领域产生重大影响，从病原体到极端微生物，并将推动药物、疫苗和工业酶研究等领域的新发展。最近的国际发展也引起了人们对微生物学的重新兴趣。目录包括评论、通信和评论的生动组合。大多数文章都是委托撰写的，所有文章都经过同行评审。因此，它们为教学和了解该领域的发展奠定了权威基础。重点是分子微生物学和病毒学，包括基因组学、植物和动物宿主-病原体相互作用的范围、宿主免疫反应、表征等主题毒力决定因素的进化、细胞周期和分化、动植物共生关系、环境微生物学、生物多样性和进化、种群动态、性别和诱变、抗生素耐药性和生产、药物和疫苗靶点，以及朊病毒疾病和真菌和原生动物生物学。

Trends in Microbiology is a multidisciplinary forum that discusses various aspects of microbiology, ranging from cell biology and immunology to genetics and evolution, covering virology, bacteriology, protozoology, and mycology. Microbiology is one of the fastest-growing disciplines today, and the life sciences have also benefited from recent technological advancements. The relative ease and speed of complete sequencing of small genomes have had a significant impact across all fields of prokaryotes, from pathogens to extremophiles, and are driving new developments in areas such as drug, vaccine, and industrial enzyme research. Recent international developments have also rekindled interest in microbiology. The journal features a vibrant mix of reviews, communications, and commentaries. Most articles are commissioned and undergo peer review, providing an authoritative foundation for teaching and understanding developments in the field. The focus is on molecular microbiology and virology, including topics such as genomics, host-pathogen interactions in plants and animals, host immune responses, the evolution of virulence determinants, cell cycle and differentiation, plant and animal symbiosis, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutation, antibiotic resistance and production, drug and vaccine targets, as well as prion diseases and the biology of fungi and protozoa.

《Trends in Microbiology》是一个多学科论坛，讨论微生物学的各个方面，包括细胞生物学、免疫学、遗传学和进化等领域，涵盖病毒学、细菌学、原生动物学和真菌学。微生物学是目前发展最快的学科之一，生命科学也因近年来的技术进步而受益。小基因组的完整测序变得相对容易和快速，这对原核生物的各个领域产生了重大影响，从病原体到极端微生物，并推动了药物、疫苗和工业酶研究等领域的新发展。最近的国际发展也引发了人们对微生物学的重新兴趣。期刊内容包括评论、通信和生动的评论组合。大多数文章都是委托撰写的，并经过同行评审，因此为教学和了解该领域的发展奠定了权威基础。重点关注分子微生物学和病毒学，包括基因组学、植物和动物宿主-病原体相互作用、宿主免疫反应、毒力决定因素的进化、细胞周期和分化、动植物共生关系、环境微生物学、生物多样性和进化、种群动态、性别和诱变、抗生素耐药性及其生产、药物和疫苗靶点，以及朊病毒疾病和真菌与原生动物生物学等主题。

Trends in Microbiology

Trends Microbiol

Control and Eradication Strategies of Hepatitis B Virus.

Recent exciting advances of new strategies, including the inhibition of viral entry, the destruction or silencing of HBV covalently closed circular DNA (cccDNA), and breaking immune tolerance are reviewed.

Category	Quartile
生物学	1
生物学, 生化与分子生物学	1
生物学, 微生物学	1

Control and Eradication Strategies of Hepatitis B Virus.

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