Background/Objectives: Endophthalmitis is an intraocular microbial infection that can lead to permanent blindness, even with prompt anti-microbial therapy. Multi-drug-resistant organisms are on the rise, potentially limiting the efficacy of current empiric antibiotic therapies of intravitreal ceftazidime and vancomycin. Cefiderocol is a recent FDA- and EMA-approved antibiotic for multi-drug-resistant Gram-negative bacteria. Methods: To better understand its potential utility in the treatment of ocular infections, the MIC of cefiderocol was compared to ceftazidime and amikacin in endophthalmitis bacterial isolates using Epsilometer testing. Because vancomycin is commonly given concomitantly as part of empiric endophthalmitis treatment, possible synergistic and antagonistic effects of concomitant vancomycin and cefiderocol were also evaluated. Results: Cefiderocol was found to have lower MIC values compared to ceftazidime for Pseudomonadales or Enterobacterales species. When comparing the MICs of cefiderocol and vancomycin, there appeared to be no antagonism between the two antibiotics. Conclusions: This is the first report exploring the use of cefiderocol in endophthalmitis strains. The results of this study show this is a promising antibiotic for multi-drug-resistant Gram-negative organisms but further research is needed to investigate its intraocular safety profile.

Brennan Schilling

Michael Hii

Hazel Q. Shanks

Eric G. Romanowski

Jonathan B. Mandell

Robert M. Q. Shanks

Michael Zegans

Antibiotics

Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.

Antibiotics is an open access, peer-reviewed journal that focuses on all aspects of antibiotics. This multidisciplinary journal encompasses the fields of biochemistry, chemistry, genetics, microbiology, and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible, and therefore, there is no restriction on the length of papers.

《Antibiotics》是一本开放获取、同行评审的期刊，专注于抗生素的各个方面。该期刊涵盖生物化学、化学、遗传学、微生物学和药理学等多个学科。我们的目标是鼓励科学家尽可能详细地发布他们的实验和理论结果，因此对论文的长度没有限制。

Category	Quartile
医学	2
医学, 药学	2
医学, 传染病学	3

Efficacy of Cefiderocol Against Endophthalmitis Isolates

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	1