Early failure of a pancreatic allograft due to complete thrombosis has an incidence of approximately 10% and is the main cause of comorbidity in pancreas transplantation. Although several risk factors have been identified, the exact mechanisms leading to this serious complication are still unclear. In this review, we define the roles of the individual components involved during sterile immunothrombosis-namely endothelial cells, platelets, and innate immune cells. Further, we review the published evidence linking the main risk factors for pancreatic thrombosis to cellular activation and vascular modifications. We also explore the unique features of the pancreas itself: the vessel endothelium, specific vascularization, and relationship to other organs-notably the spleen and adipose tissue. Finally, we summarize the therapeutic possibilities for the prevention of pancreatic thrombosis depending on the different mechanisms such as anticoagulation, anti-inflammatory molecules, endothelium protectors, antagonism of DAMPs, and use of machine perfusion.

Christophe Masset

Nicolas Drillaud

Catherine Ternisien

Nicolas Degauque

Nathalie Gerard

Sarah Bruneau

Julien Branchereau

Gilles Blancho

Benoit Mesnard

Sophie Brouard

Magali Giral

Diego Cantarovich

Jacques Dantal

American Journal of Transplantation

范围是国际移植学科。这包括器官和组织的捐赠和保存；组织损伤、修复、炎症和老化；免疫识别、调节、效应机制和诱导耐受的机会；组织相容性；与移植相关的药物和药理学；移植物存活和预防移植物功能障碍和失败；临床试验和人群分析；移植并发症；异种移植；以及伦理和社会问题。科学包括细胞生物学、医学、外科、儿科和传染病的相关方面。该杂志包括胸腔移植（心脏、肺）、腹部移植（肾、肝、胰腺、胰岛）、组织移植和相关主题。

The American Journal of Transplantation is a journal that covers the field of international transplantation. This includes organ and tissue donation and preservation; tissue injury, repair, inflammation, and aging; immune recognition, regulation, mechanisms of action, and opportunities for inducing tolerance; tissue compatibility; drugs and pharmacology related to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses; transplant complications; xenotransplantation; as well as ethical and social issues. The scientific scope includes relevant aspects of cell biology, medicine, surgery, pediatrics, and infectious diseases. The journal covers thoracic transplantation (heart, lung), abdominal transplantation (kidney, liver, pancreas, islet), tissue transplantation, and related topics.

《American Journal of Transplantation》是一个涵盖国际移植学科的期刊，内容包括器官和组织的捐赠与保存、组织损伤与修复、炎症与老化、免疫识别与调节机制、组织相容性、与移植相关的药物与药理学、移植物存活及预防移植物功能障碍和失败的研究、临床试验与人群分析、移植并发症、异种移植以及伦理与社会问题。该期刊涉及细胞生物学、医学、外科、儿科和传染病等相关领域，涵盖胸腔移植（心脏、肺）、腹部移植（肾、肝、胰腺、胰岛）、组织移植及相关主题。

Am J Transplant

The concept of immunothrombosis in pancreas transplantation

胰腺移植中的免疫血栓形成概念

Category	Quartile
医学	2
医学, 移植	1
医学, 外科	2

The concept of immunothrombosis in pancreas transplantation

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