Editorial FocusCeramide toxicity in cardiomyocytes: From Farber Disease to CVDLindsey A. Fitzsimons, Harilaos Filippakis, Lindsey A. FitzsimonsCorrespondence: Lindsey A. Fitzsimons Biomedical Sciences, University of New England 11 Hills Beach Rd Pickus Center, Central Receiving Biddeford, ME 04005 lfitzsimons@une.eduPortland Laboratory for Biotechnology and Health Sciences, University of New England, Portland, ME, USACenter for Excellence in Neurosciences, University of New England, Biddeford, ME, USADepartment of Biomedical Sciences, University of New England, College of Osteopathic Medicine, Biddeford, ME, USACenter for Cell Signaling Research, University of New England, Biddeford, ME, USA and Harilaos FilippakisCenter for Excellence in Neurosciences, University of New England, Biddeford, ME, USADepartment of Biomedical Sciences, University of New England, College of Osteopathic Medicine, Biddeford, ME, USACenter for Cell Signaling Research, University of New England, Biddeford, ME, USAPublished Online:20 Dec 2024https://doi.org/10.1152/ajpheart.00843.2024MoreFiguresReferencesRelatedInformationPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookXLinkedInWeChat We recommendHigh [Na+]i in cardiomyocytes from rainbow troutRikke Birkedal, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2007Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytesAlexandra Dainis, Physiological Genomics, 2020Recovery of anoxic-reoxygenated cardiomyocytes from severe Ca2+ overloadB. Siegmund, American Journal of Physiology - Heart and Circulatory Physiology, 1992Calcium homeostasis in cardiomyocytes isolated from heat-shocked ratsR. N. Cornelussen, American Journal of Physiology - Heart and Circulatory Physiology, 1996Cardiomyocytes from postinfarction failing rat hearts have improved ischemia toleranceMohammad Nouri Sharikabad, American Journal of Physiology - Heart and Circulatory Physiology, 2009Powered by Privacy policyGoogle Analytics settings Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation More from this issue > Articles in PressPublished 20 Dec 2024 Crossmark Copyright & PermissionsCopyright © 2025 the American Physiological Societyhttps://doi.org/10.1152/ajpheart.00843.2024PubMed39705588History Received 3 December 2024 Accepted 9 December 2024 Published online 20 December 2024 KeywordsACDaseCeramideFarber Diseasecardiomyocytelysosome Metrics We recommendHigh [Na+]i in cardiomyocytes from rainbow troutRikke Birkedal, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2007Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytesAlexandra Dainis, Physiological Genomics, 2020Recovery of anoxic-reoxygenated cardiomyocytes from severe Ca2+ overloadB. Siegmund, American Journal of Physiology - Heart and Circulatory Physiology, 1992Calcium homeostasis in cardiomyocytes isolated from heat-shocked ratsR. N. Cornelussen, American Journal of Physiology - Heart and Circulatory Physiology, 1996Cardiomyocytes from postinfarction failing rat hearts have improved ischemia toleranceMohammad Nouri Sharikabad, American Journal of Physiology - Heart and Circulatory Physiology, 2009Powered by Privacy policyGoogle Analytics settings publications0supporting0mentioning0contrasting0Smart Citations0000Citing PublicationsSupportingMentioningContrastingView CitationsSee how this article has been cited at scite.aiscite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Lindsey A. Fitzsimons

Harilaos Filippakis

AJP Heart and Circulatory Physiology

美国生理学杂志-心脏和循环生理学发表关于心脏、脉管系统和淋巴系统生理学的原始调查、评论和观点。这些文章包括从完整和整合的动物和器官功能到细胞、亚细胞和分子水平的各个组织水平的心血管功能的实验和理论研究。该杂志包含了对这些功能及其控制系统的新描述，以及它们在生物化学、生物物理学、遗传学和细胞生物学中的基础。优先考虑提供重要的新机械生理学见解的研究，这些见解可以确定正常和异常心脏和循环的表现。

The American Journal of Physiology - Heart and Circulatory Physiology publishes original investigations, reviews, and perspectives on the physiology of the heart, vascular system, and lymphatic system. These articles cover experimental and theoretical studies of cardiovascular function at various levels, from whole and integrated animal and organ functions to cellular, subcellular, and molecular levels. The journal includes new descriptions of these functions and their control systems, as well as their foundations in biochemistry, biophysics, genetics, and cell biology. Research providing significant new insights into mechanical physiology that can elucidate the performance of normal and abnormal heart and circulatory functions is prioritized.

《American Journal of Physiology - Heart and Circulatory Physiology》发表关于心脏、血管系统和淋巴系统生理学的原创研究、评论和观点。这些文章涵盖了从整体和综合的动物及器官功能到细胞、亚细胞和分子水平的心血管功能的实验和理论研究。该杂志包含对这些功能及其控制系统的新描述，以及它们在生物化学、生物物理学、遗传学和细胞生物学中的基础。优先考虑提供重要的新机械生理学见解的研究，这些见解能够阐明正常和异常心脏及循环的表现。

Category	Quartile
医学	2
医学, 生理学	2
医学, 心脏和心血管系统	3
医学, 外周血管病	3

Ceramide toxicity in cardiomyocytes: From Farber Disease to CVD

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