Polymersomes have the potential to become the next generation of vesicular drug delivery systems. Their high chemical versatility and in certain cases higher membrane stability than liposomes raised the high hopes for polymersomes as a drug carrier, but the clinical translation has been slow. To jump-start translation, there is a need for meticulous characterization and reporting of key parameters of polymersome formulations. Regulatory authorities have provided valuable insights on critical quality attributes of liposomes in their guidance document on liposomal nanosimilars. Inspired by this guidance document, this Perspective proposes necessary characterization of polymersomes (hallmarks) regarding their chemical composition, physicochemical properties, drug release profile, stability, stimuli responsiveness, and pharmacokinetics and biodistribution.

Simon Matoori

ACS Materials Au

ACS Materials Au是一本开放获取期刊，发表描述基础和应用研究前沿的高质量研究成果，以及材料与其他学科（如化学，工程和生物学）之间的交叉科学研究。期刊特别欢迎展示多学科和创新材料研究以应对全球挑战的论文。

期刊收录研究方向：
前沿和新兴材料的设计、合成、表征和评估
了解结构、属性、性能关系及其基础机制
开发用于能源、环境、生物医学、电子和催化应用的材料
ACS Materials Au is an open access journal publishing letters, articles, reviews and perspectives describing high-quality research at the forefront of fundamental and applied research, and at the interface between materials and other disciplines, such as chemistry, engineering and biology. Papers that showcase multidisciplinary and innovative materials research addressing global challenges are especially welcome. Areas of interest include, but are not limited to:

Design, synthesis, characterization, and evaluation of forefront and emerging materials
Understanding structure, property, performance relationships and their underlying mechanisms
Development of materials for energy, environmental, biomedical, electronic, and catalytic applications

ACS Materials Au is an open access journal that publishes high-quality research results in fundamental and applied research, with a particular focus on interdisciplinary studies at the interface of materials science and other fields such as chemistry, engineering, and biology. The journal welcomes papers that showcase multidisciplinary and innovative materials research aimed at addressing global challenges. Areas of interest include: design, synthesis, characterization, and evaluation of forefront and emerging materials; understanding the relationships between structure, properties, and performance, along with their underlying mechanisms; and the development of materials for energy, environmental, biomedical, electronic, and catalytic applications.

ACS Materials Au 是一本开放获取期刊，发表高质量的基础和应用研究成果，特别关注材料科学与化学、工程和生物学等其他学科之间的交叉研究。期刊欢迎展示多学科和创新材料研究，以应对全球挑战的论文。期刊的研究方向包括：前沿和新兴材料的设计、合成、表征和评估；理解结构、属性和性能之间的关系及其基础机制；开发用于能源、环境、生物医学、电子和催化应用的材料。

Hallmarks of Polymersome Characterization

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Journal Info

Category	Quartile
MATERIALS SCIENCE, MULTIDISCIPLINARY	2