The local sweat rate (LSR) response to intradermal electrical stimulation generates a sigmodal stimulus-response curve with a peak sweat rate generated during a 30 s period of continuous stimuli at a frequency of 16 to 32 Hz. However, the in vivo firing pattern of the sudomotor nerve resembles more of a bursting pattern. We tested the hypothesis that a bursting pattern during intradermal electrical stimulation would result in a greater sweating response than the regular continuous stimulus pattern. 15 subjects were studied in a temperature-controlled room at 27.6 ± 0.2 {degree sign}C. The LSR was measured with a miniature sweat capsule with guide sleeves for holding the intradermal stimulating electrodes. The nine continuous stimulus frequencies (0.2, 1, 2, 4, 8, 12, 16, 32, and 64 Hz) were compared to a bursting pattern with a similar total number of stimuli. The sweating response was determined as the area under the LSR-time curve. Peak LSR was slightly higher for the continuous stimuli (0.396 ± 0.242 mg • min -1 • cm -2 ,p = 0.023) than for the bursting stimuli (0.356 ± 0.244 mg • min -1 • cm -2 ). The sigmoidal shaped stimulus response curves, however, were significantly different (p = 0.0007). The EC 50 (p = 0.0029) was higher during continuous stimulation and the Hill slope was lower (p&lt;0.0001) during bursting stimuli. These data do not support the concept that a bursting stimulus pattern during intradermal electrical stimulation evokes a greater LSR.

Gary W. Mack

Kaylee M. Bahr

Christian J. McEwan

Carson J. Price

Ashton J. Renfro

AJP Regulatory Integrative and Comparative Physiology

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARISON PHYSIOLOGY 发表了原创研究，阐明了从分子到人类的各个层面的生理机制的正常或异常调节和整合，包括临床研究。重点领域包括对转基因动物的监管；模式生物；发育和组织可塑性；循环和高血压的神经体液控制；局部循环控制；心脏和肾脏整合；口渴和容量，电解质稳态；葡萄糖稳态和能量平衡；食欲和肥胖；炎症和细胞因子；妊娠-分娩-哺乳的综合生理学；以及对运动和环境压力的体温调节和适应。

The American Journal of Physiology - Regulatory Integrative and Comparative Physiology publishes original research that elucidates the normal and abnormal regulation and integration of physiological mechanisms across various levels, from molecules to humans, including clinical studies. Key areas of focus include the regulation of transgenic animals, model organisms, developmental and tissue plasticity, neurohumoral control of circulation and hypertension, local circulation control, integration of cardiac and renal functions, thirst and volume, electrolyte homeostasis, glucose homeostasis and energy balance, appetite and obesity, inflammation and cytokines, the integrative physiology of pregnancy, childbirth, and lactation, as well as thermoregulation and adaptation to exercise and environmental stress.

《American Journal of Physiology - Regulatory Integrative and Comparative Physiology》发表原创研究，阐明从分子到人类各个层面的生理机制的正常与异常调节和整合，包括临床研究。重点领域包括转基因动物的调控、模式生物、发育与组织可塑性、循环与高血压的神经体液控制、局部循环控制、心脏与肾脏的整合、口渴与容量、电解质稳态、葡萄糖稳态与能量平衡、食欲与肥胖、炎症与细胞因子、妊娠-分娩-哺乳的综合生理学，以及对运动与环境压力的体温调节与适应。

Category	Quartile
医学	3
医学, 生理学	3

Intradermal electrical stimulation of sudomotor nerves and local sweat rate.

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info