The carboxy-terminus of Hsc70 interacting protein (CHIP) is a cochaperone E3 ligase containing three tandem repeats of tetratricopeptide (TPR) motifs and a C-terminal U-box domain separated by a charged coiled-coil region. CHIP is known to function as a central quality control E3 ligase and regulates several proteins involved in a myriad of physiological and pathological processes. Recent studies have highlighted varied regulatory mechanisms operating on the activity of CHIP which is crucial for cellular homeostasis. In this review article, we give a concise account of our current knowledge on the biochemistry and regulation of CHIP.

Indranil Paul

Mrinal K. Ghosh

BioMed Research International

BIOMED RESEARCH INTERNATIONAL 是一份经过同行评审的开放获取期刊，发表原创研究文章、评论文章和临床研究，涵盖生命科学和医学领域的广泛主题。该杂志分为55个学科领域。

BioMed Research International is a peer-reviewed open access journal that publishes original research articles, review articles, and clinical studies covering a wide range of topics in the life sciences and medicine. The journal is divided into 55 subject areas.

《BioMed Research International》是一份经过同行评审的开放获取期刊，专注于发表原创研究文章、评论文章和临床研究，涵盖生命科学和医学领域的广泛主题。该期刊分为55个学科领域。

The E3 Ligase CHIP: Insights into Its Structure and Regulation

This review article gives a concise account of the current knowledge on the biochemistry and regulation of CHIP.

Category	Quartile
生物学	3
生物学, 生物工程与应用微生物	3
生物学, 医学研究与实验	4

The E3 Ligase CHIP: Insights into Its Structure and Regulation

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