ABSTRACT Introduction The common genetic underpinnings of psoriasis and pulmonary comorbidities have yet to be explored. Material and Methods In this cross‐sectional study, we investigated the single‐nucleotide polymorphisms (SNPs) associated with psoriasis and their relationship with pulmonary function using data from the UK Biobank (UKBB) and the Vanderbilt University Medical Center Biobank (BioVU). Results Out of the 63 psoriasis‐associated SNPs identified in previous genome‐wide association studies within the European population, we successfully identified 53 SNPs, including proxy SNPs in UKBB database. Following adjustments using age and sex, 31 SNPs displayed statistically significant associations with psoriasis. Among these, 16 SNPs exhibited significant associations with forced expiratory volume in 1 s (FEV 1 ), 14 with forced vital capacity (FVC), and 5 with the FEV 1 /FVC ratio in the UKBB. In the validation analysis using the BioVU database, 27 of the 31 psoriasis‐associated SNPs were available for examination. Notably, the minor allele of SNP rs8016947 was confirmed to be significant, indicating a reduced risk for psoriasis and improved FEV 1 . Similarly, the minor alleles of SNPs rs17716942 and rs8016947 were associated with a reduced risk of psoriasis and enhanced FVC. However, none of the 5 SNPs significantly associated with the FEV 1 /FVC ratio in the UKBB displayed significance in the BioVU dataset. Conclusion This study has unveiled genetic variants that bridge the realms of psoriasis and lung function. The genes associated with these variants, including IFIH1 , Grancalcin gene ( GCA ), and NFKB inhibitor alpha gene ( NFKBIA ), regulate innate immune responses, which suggests that immunodysregulation, a central element in psoriasis pathogenesis, may also impact lung function, alluding to a “skin–lung axis.”

Kazuya Tanimura

Melinda C. Aldrich

James Jaworski

Jinchuan Xing

Satoshi Okawa

Divay Chandra

Seyed M. Nouraie

Toru Nyunoya

Annals of Human Genetics

人类遗传学年鉴出版与人类遗传学或科学原理和技术在人类遗传任何方面的应用直接相关的材料。还将考虑描述可能与人类遗传学相关的其他物种的工作的论文。数学模型应尽可能包括数据应用示例。欢迎作者提交支持信息，例如数据集或其他图形或表格，这些信息不会在期刊的印刷版中发布，但可通过在线版本并存储在网站上。

The Annals of Human Genetics publishes research materials directly related to human genetics and the application of scientific principles and techniques in any aspect of human genetics. We also welcome papers describing work related to other species that may be relevant to human genetics. All mathematical models should include examples of data applications whenever possible. Authors are encouraged to submit supporting information, such as datasets or other graphics and tables, which will not be published in the print version of the journal but will be made available in the online version and stored on our website.

《Annals of Human Genetics》期刊出版与人类遗传学及其在各个领域的应用相关的研究材料。我们也欢迎与其他物种相关的研究论文，这些研究可能对人类遗传学有启发。所有数学模型应尽量包含数据应用的实例。我们鼓励作者提交支持性信息，例如数据集、图形或表格，这些信息将不会在期刊的印刷版中发布，但会在在线版本中提供，并存储在我们的网站上。

Category	Quartile
生物学	4
生物学, 遗传学	4

Identifying a Genetic Link Between Lung Function and Psoriasis

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Journal Info

Category	Quartile
GENETICS & HEREDITY	4