Experimental models of Alzheimer's disease (AD) are critical to gaining a better understanding of pathogenesis and to assess the potential of novel therapeutic approaches. The most commonly used experimental animal models are transgenic mice that overexpress human genes associated with familial AD (FAD) that result in the formation of amyloid plaques. However, AD is defined by the presence and interplay of both amyloid plaques and neurofibrillary tangle pathology. The track record of success in AD clinical trials thus far has been very poor. In part, this high failure rate has been related to the premature translation of highly successful results in animal models that mirror only limited aspects of AD pathology to humans. A greater understanding of the strengths and weakness of each of the various models and the use of more than one model to evaluate potential therapies would help enhance the success of therapy translation from preclinical studies to patients. In this review, we summarize the pathological features and limitations of the major experimental models of AD, including transgenic mice, transgenic rats, various physiological models of sporadic AD and in vitro human cell culture models.

Eleanor Drummond

Thomas Wisniewski

Acta neuropathologica

ACTA NEUROPATHOLOGICA 旨在发表关于神经疾病病理学的最佳论文，以及使用体外和体内模型对分子和细胞机制进行的实验研究，并通过人体组织分析进行理想验证。该期刊发表原创论文、评论文章、案例报告和科学通信（信件）。提交出版的手稿必须包含声明，说明所有人体研究都已由相应的伦理委员会审查，因此已按照适当版本的伦理标准进行1964 年赫尔辛基宣言。还应在正文中明确说明所有人员在纳入研究之前均已签署知情同意书。应省略可能披露研究对象身份的细节。动物实验报告必须说明遵循“实验动物护理原则”（NIH 出版物第 86-23 号，1985 年修订），以及特定的国家适用的法律（例如当前版本的德国动物保护法）。编辑保留拒绝不符合上述要求的稿件的权利。作者将承担虚假陈述或未能满足上述要求的责任。

Acta Neuropathologica aims to publish high-quality papers on the pathology of neurological diseases, including experimental studies on molecular and cellular mechanisms using in vitro and in vivo models, validated through human tissue analysis. The journal accepts original research articles, review articles, case reports, and scientific communications (letters). All submitted manuscripts must include a statement indicating that all human research has been reviewed by the appropriate ethics committee and conducted in accordance with the appropriate version of the ethical standards of the Declaration of Helsinki (1964). Furthermore, the main text should clearly state that all participants signed informed consent prior to inclusion in the study, and details that could disclose the identity of research subjects should be omitted. Reports of animal experiments must indicate adherence to the 'Principles of Laboratory Animal Care' (NIH Publication No. 86-23, revised 1985) and relevant national laws (e.g., the current version of the German Animal Protection Act). The editor reserves the right to reject manuscripts that do not meet these requirements, and authors will be held responsible for false statements or failure to comply with the above requirements.

《Acta Neuropathologica》旨在发表关于神经疾病病理学的高质量论文，涵盖使用体外和体内模型研究分子和细胞机制的实验研究，并通过人体组织分析进行验证。该期刊接受原创论文、评论文章、案例报告和科学通信（信件）。所有提交的手稿必须包含声明，表明所有人体研究均已通过相应伦理委员会的审查，并遵循1964年赫尔辛基宣言的适当版本的伦理标准。此外，正文中应明确说明所有参与者在研究纳入前均已签署知情同意书，且应省略可能揭示研究对象身份的细节。动物实验报告必须说明遵循“实验动物护理原则”（NIH出版物第86-23号，1985年修订）以及适用的国家法律（例如当前版本的德国动物保护法）。编辑有权拒绝不符合上述要求的稿件，作者需对虚假陈述或未能满足上述要求承担责任。

Acta Neuropathologica

Acta Neuropathol

Alzheimer's disease: experimental models and reality.

A greater understanding of the strengths and weakness of each of the various models and the use of more than one model to evaluate potential therapies would help enhance the success of therapy translation from preclinical studies to patients.

Category	Quartile
医学	1
医学, 临床神经病学	1
医学, 神经科学	1
医学, 病理学	1

Alzheimer's disease: experimental models and reality.

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