Here, we present three-dimensional-printed dual-channel flow-through miniaturized devices (3Dd) with dual electrochemical detection (EDd) integrating two working electrodes each in an in-channel configuration (3Dd-EDd). Prussian Blue (PB) shell-gold nanoparticles ((PB)AuNP) core-based electrochemistry was chosen for selective hydrogen peroxide determination. 3Dd-EDd devices exhibited impress stability, identical intrachannel and interchannel electrochemical performances, and excellent interdevice precision with values under 9%, revealing the reliability of the design and fabrication of the devices. 3Dd-EDd enabled long-term reliable hydrogen peroxide determination at physiological pH in Caco-2 cells under prooxidant stimulation demonstrating its outstanding electroanalytical performance. The results highlight the analytical versatility and trustworthiness of 3D-printing-based devices at miniaturized scale integrating advanced electrochemistry and its potential for real-time cell monitoring.

Miriam Chávez

Alberto Escarpa

Analytical Chemistry

ANALYTICAL CHEMISTRY 是一份经过同行评审的研究期刊，致力于传播分析化学所有分支的新知识和原创知识。基础文章可能涉及化学测量科学的一般原则，不需要直接涉及现有或潜在的分析方法。文章在分析方面可能完全是理论性的，或者它们可能会报告实验结果。它们可能有助于分析操作的任何阶段，包括采样、生物分析、电化学、质谱、微米级和纳米级系统和结构、环境分析、分离、光谱学、化学反应和选择性、仪器仪表、成像、表面分析和数据处理。处理已知分析方法的论文应提供该方法的重要、原始应用、显着改进或对重要分析物的结果。还有：肛门化学。

Analytical Chemistry is a peer-reviewed research journal dedicated to disseminating new knowledge and original research across all branches of analytical chemistry. The foundational articles published may address general principles of chemical measurement science without needing to directly relate to existing or potential analytical methods. These articles can be entirely theoretical or may report experimental results, contributing to any stage of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, micro and nanoscale systems and structures, environmental analysis, separation techniques, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers dealing with known analytical methods should provide significant, original applications, substantial improvements, or results for important analytes.

《Analytical Chemistry》是一本经过同行评审的研究期刊，致力于传播分析化学各个分支的新知识和原创研究。期刊发表的基础文章可能涉及化学测量科学的一般原则，而不必直接关联现有或潜在的分析方法。这些文章可以是完全理论性的，或者报告实验结果，涵盖分析操作的各个阶段，包括采样、生物分析、电化学、质谱、微米级和纳米级系统与结构、环境分析、分离技术、光谱学、化学反应与选择性、仪器仪表、成像、表面分析和数据处理。处理已知分析方法的论文应提供该方法的重要应用、显著改进或对重要分析物的结果。

Category	Quartile
化学	1
化学, 分析化学	1

3D-Printed Dual-Channel Flow-Through Miniaturized Devices with Dual In-Channel Electrochemical Detection

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