Chemotherapy-induced cardiotoxicity is a significant concern in cancer treatment, as certain chemotherapeutic agents can have adverse effects on the cardiovascular system. This can lead to a range of cardiac complications, including heart failure, arrhythmias, myocardial dysfunction, pericardial complications, and vascular toxicity. Strategies to mitigate chemotherapy-induced cardiotoxicity may include the use of cardioprotective agents (e.g., dexrazoxane), dose adjustments, alternative treatment regimens, and the implementation of preventive measures, such as lifestyle modifications and the management of cardiovascular risk factors. Ginsenosides, the active compounds found in ginseng (Panax ginseng), have been studied for their potential cardioprotective effects in the context of chemotherapy-induced cardiotoxicity. In this review, we investigate the cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity. Ginsenosides have been shown to possess potent antioxidant properties, which can help mitigate the oxidative stress and inflammation associated with chemotherapy-induced cardiac injury. They can modulate the expression of antioxidant enzymes and reduce the production of reactive oxygen species, thereby protecting cardiomyocytes from damage. Ginsenosides can also inhibit apoptosis (programmed cell death) of cardiomyocytes, which is a key mechanism underlying chemotherapy-induced cardiotoxicity. Modulation of ion channels, improvement of lipid profiles, anti-platelet and anti-thrombotic effects, and promotion of angiogenesis and neovascularization are another important mechanisms behind potential effects of ginsenosides on cardiovascular health. Ginsenosides can improve various parameters of cardiac function, such as ejection fraction, fractional shortening, and cardiac output, in animal models of chemotherapy-induced cardiotoxicity. The cardioprotective effects of ginsenosides have been observed in preclinical studies using various chemotherapeutic agents, including doxorubicin, cisplatin, and 5-fluorouracil. However, more clinical studies are needed to fully elucidate the therapeutic potential of ginsenosides in preventing and managing chemotherapy-induced cardiotoxicity in cancer patients.

Hadi Zare-Zardini

Mohammad-Taghi Hedayati-Goudarzi

Ameneh Alizadeh

Fatemeh Sadeghian-Nodoushan

Hossein Soltaninejad

BioMedical Engineering OnLine

BIOMEDICAL ENGINEERING ONLINE 是一本开放获取、同行评议的期刊，致力于发表生物医学工程所有领域的研究成果。BIOMEDICAL ENGINEERING ONLINE 面向世界各地对使用物理和数据科学工具感兴趣的读者和作者和工程技术，以理解和解决生物和医学科学中的问题。主题领域包括但不限于：生物信息学-生物仪器-生物力学-生物医学设备和仪器-生物医学信号处理-医疗信息系统-人体动力学-神经工程-康复工程-生物材料-生物医学成像和图像处理-生物微机电系统和 ON-芯片设备-生物微/纳米技术-生物分子工程-生物传感器-心血管系统工程-细胞工程-临床工程-计算生物学-药物输送技术-建模方法-生物医学中的纳米材料和纳米技术-呼吸系统工程-医学中的机器人-系统和合成生物学-系统生物学-远程医疗/智能手机在医学中的应用-治疗系统、设备和技术-组织工程

BioMedical Engineering Online is an open-access, peer-reviewed journal dedicated to publishing research findings in all areas of biomedical engineering. The journal targets readers and authors worldwide who are interested in using physical and data science tools to understand and solve problems in biological and medical sciences. The topics covered include but are not limited to: bioinformatics, biomedical instrumentation, biomechanics, biomedical devices and instruments, biomedical signal processing, medical information systems, human kinetics, neural engineering, rehabilitation engineering, biomaterials, biomedical imaging and image processing, bio-MEMS and on-chip devices, bio-micro/nanotechnology, biomolecular engineering, biosensors, cardiovascular system engineering, cellular engineering, clinical engineering, computational biology, drug delivery technologies, modeling methods, nanomaterials and nanotechnology in biomedicine, respiratory system engineering, robotics in medicine, systems and synthetic biology, systems biology, telemedicine/smartphone applications in medicine, therapeutic systems, devices and technologies, and tissue engineering.

《BioMedical Engineering Online》是一本开放获取、同行评审的期刊，专注于生物医学工程领域的研究成果。该期刊面向全球对物理和数据科学工具在生物和医学科学中应用感兴趣的读者和作者，旨在理解和解决相关问题。主题涵盖但不限于：生物信息学、生物仪器、生物力学、生物医学设备和仪器、生物医学信号处理、医疗信息系统、人体动力学、神经工程、康复工程、生物材料、生物医学成像和图像处理、生物微机电系统和芯片设备、生物微/纳米技术、生物分子工程、生物传感器、心血管系统工程、细胞工程、临床工程、计算生物学、药物输送技术、建模方法、生物医学中的纳米材料和纳米技术、呼吸系统工程、医学中的机器人、系统和合成生物学、系统生物学、远程医疗/智能手机在医学中的应用、治疗系统、设备和技术、组织工程。

Category	Quartile
医学	4
医学, 工程生物医学	4

A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity

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