Questions in cancer have engaged systems biologists for decades. During that time, the quantity of molecular data has exploded, but the need for abstractions, formal models, and simplifying insights has remained the same. This review brings together classic breakthroughs and recent findings in the field of cancer systems biology, focusing on cancer-cell pathways for tumorigenesis and therapeutic response. Cancer cells mutate and transduce information from their environment to alter gene expression, metabolism, and phenotypic states. Understanding the molecular architectures that make each of these steps possible is a long-term goal of cancer systems biology pursued by iterating between quantitative models and experiments. We argue that such iteration is the best path to deploying targeted therapies intelligently so that each patient receives the maximum benefit for their cancer.

Kevin A. Janes

Matthew J. Lazzara

Annual Review of Biomedical Engineering

自 1999 年出版的《生物医学工程年度回顾》涵盖了生物医学工程广泛领域的重大发展，包括生物力学、生物材料、计算基因组学和蛋白质组学、组织工程、生物监测、医疗保健工程、药物输送、生物电工程、生化工程和生物医学成像主题。

The Annual Review of Biomedical Engineering, published since 1999, covers significant developments across a wide range of topics in biomedical engineering, including biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biosensing, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging.

《Annual Review of Biomedical Engineering》自1999年出版，涵盖了生物医学工程领域的多个重要主题，包括生物力学、生物材料、计算基因组学与蛋白质组学、组织工程、生物监测、医疗工程、药物输送、生物电工程、生化工程以及生物医学成像等。

Category	Quartile
工程技术	1
工程技术, 工程生物医学	1

Systems Biology of the Cancer Cell

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	1