Hepatic sinusoidal obstruction syndrome (HSOS) has gained recognition as a rare form of drug-induced liver injury (DILI) in recent years. Although extensively studied in the context of hematopoietic stem cell transplantation (HSCT), the applicability of this knowledge to drug-induced HSOS remains limited due to distinct etiological factors. The primary causes of drug-induced HSOS include the ingestion of pyrrolizidine alkaloid (PA)-containing plants, as well as the use of chemotherapeutic agents and immunosuppressive drugs. The underlying pathogenesis is not yet fully understood. Noninvasive diagnostic imaging modalities such as ultrasonography, computed tomography, and magnetic resonance imaging play a valuable role in diagnosis. Further research is essential to develop standardized severity grading systems and optimize treatment strategies. This review summarizes the key etiologies, pathological mechanisms, clinical features, diagnostic approaches, severity assessment, and therapeutic options for drug-induced HSOS.

Zaoqin Yu

Wei Li

Cheng Tian

Yan Cao

Chengliang Zhang

Archives of Toxicology

毒理学档案提供有关毒理学最新进展的最新信息。该杂志特别强调与化学物质的明确影响和毒性机制相关的研究，包括分子水平的毒性活动，在人类和实验动物中。覆盖范围包括对分析和毒代动力学以及法医毒理学的新见解。毒理学家普遍感兴趣的评论文章是该杂志的另一个重要特征。

The Archives of Toxicology is a journal that provides the latest information on advancements in toxicology. It particularly emphasizes research related to the effects of chemicals and their toxic mechanisms, including toxic activities at the molecular level in humans and experimental animals. The scope includes new insights into analytical toxicology, toxicokinetics, and forensic toxicology. Additionally, review articles that are of general interest to toxicologists are another significant feature of the journal.

《Archives of Toxicology》是一本提供毒理学最新进展的期刊。该杂志特别强调与化学物质的影响及其毒性机制相关的研究，包括分子水平的毒性活动，涉及人类和实验动物。内容涵盖对分析毒理学、毒代动力学以及法医毒理学的新见解。此外，毒理学家普遍感兴趣的评论文章也是该杂志的重要特色之一。

Category	Quartile
医学	2
医学, 毒理学	1

Drug-induced hepatic sinusoidal obstruction syndrome: current advances and future perspectives

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