Gene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The realization that gene therapy applications were much vaster has opened up endless opportunities for therapeutic genetic manipulations, especially in the skin and external wounds. Cutaneous wound healing is a complicated, multistep process with numerous mediators that act in a network of activation and inhibition processes. Gene delivery in this environment poses a particular challenge. Numerous models of gene delivery have been developed, including naked DNA application, viral transfection, high-pressure injection, liposomal delivery, and more. Of the various methods for gene transfer, cationic cholesterol-containing liposomal constructs are emerging as a method with great potential for non-viral gene transfer in the wound. This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field.

L K Branski

C T Pereira

D N Herndon

M G Jeschke

Gene therapy

基因疗法涵盖了基于遗传成分的新型治疗技术的研究和临床应用。在过去的几十年里，从识别导致疾病的新遗传靶点到显示治疗益处的临床研究，技术的重大进步已将这一多学科领域提升到现代医学的前沿。

Gene Therapy is a field that focuses on the research and clinical application of novel therapeutic techniques based on genetic components. In recent decades, significant advancements in technology have elevated this multidisciplinary field to the forefront of modern medicine, from identifying new genetic targets that cause diseases to demonstrating therapeutic benefits in clinical studies.

基因疗法是研究和临床应用基于遗传成分的新型治疗技术的领域。近年来，随着对导致疾病的新遗传靶点的识别以及临床研究中治疗效果的展示，这一多学科领域的技术进步显著，已将其提升至现代医学的前沿。

Gene Therapy

Gene Ther

Gene therapy in wound healing: present status and future directions.

Of the various methods for gene transfer, cationic cholesterol-containing liposomal constructs are emerging as a method with great potential for non-viral gene transfer in the wound, and possible future directions in this exciting field are reviewed.

Category	Quartile
医学	3
医学, 生物工程与应用微生物	2
医学, 生化与分子生物学	3
医学, 遗传学	3
医学, 医学研究与实验	3

Gene therapy in wound healing: present status and future directions.

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Journal Info

Category	Quartile
MEDICINE, RESEARCH & EXPERIMENTAL	2