Wound healing is a complex process that involves interaction of soluble mediators, extracellular matrix and infiltrating blood cells. Chronic and non-healing skin defects contribute significantly to morbidity and mortality of many patients. Recently, despite the current medical progress, the chronic and non-healing wounds still represent a serious medical problem. In many cases, conventional therapeutic approaches, such as dermal substitutes and growth factor therapy failed and do not produce the expected results, patients are exposed to a high risk of infection, sepsis or amputation. For that reason clinicians and researchers are forced to searching for alternative methods to induce healing process which may result into complete wound closure. Mesenchymal stem cells (MSCs) represent a unique tool of tissue engineering and regenerative medicine and a promising therapeutic strategy. Due to their unique biological properties, MSCs seem to be the perspective modality method for these patients. Many preclinical and clinical studies suggest the possibility of using these cells in tissue regeneration, healing acute and chronic wounds and scar remodelling. The objective of the present review is to summarize the current information and preclinical data about MSCs, their biological characteristics and mode of action during regenerative and healing processes, as well as their clinical application in chronic wounds treatment.

Peter Zahorec

Jan Koller

Lubos Danisovic

Martin Bohac

Cell and tissue banking

细胞和组织库提供了一个向参与细胞和组织库和移植的科学家和临床医生传播信息的论坛。 CELL AND TISSUE BANKING 是一份国际同行评审期刊，发表以下领域的原创论文：关于组织银行一般方面的基础研究，例如储存细胞/组织的质量保证和控制、保存和灭菌方法对细胞/组织、生物技术等；储存细胞/组织的临床应用；细胞/组织采购、加工、储存和分配的实践标准；伦理道德问题;法医问题。

Cell and Tissue Banking is an international peer-reviewed journal that provides a forum for scientists and clinicians involved in cell and tissue banking and transplantation to disseminate information. The journal publishes original research papers in the following areas: fundamental research on general aspects of tissue banking, such as quality assurance and control for the storage of cells/tissues, the effects of preservation and sterilization methods on cells/tissues, biotechnology, etc.; clinical applications of stored cells/tissues; practical standards for the procurement, processing, storage, and distribution of cells/tissues; ethical issues; and forensic matters.

《Cell and Tissue Banking》是一个国际同行评审期刊，旨在为参与细胞和组织库及移植的科学家和临床医生提供一个信息交流的平台。期刊发表原创研究论文，涵盖以下领域：关于组织银行的基础研究，包括细胞和组织的质量保证与控制、保存和灭菌方法对细胞和组织的影响、生物技术等；细胞和组织的临床应用；细胞和组织的采购、加工、储存和分配的实践标准；伦理道德问题以及法医问题。

Cell and Tissue Banking

Cell Tissue Bank

Mesenchymal stem cells for chronic wounds therapy.

The objective of the present review is to summarize the current information and preclinical data about MSCs, their biological characteristics and mode of action during regenerative and healing processes, as well as their clinical application in chronic wounds treatment.

Category	Quartile
医学	4
医学, 细胞生物学	4
医学, 工程生物医学	4

Mesenchymal stem cells for chronic wounds therapy.

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	4