Summary This study addresses the diagnostic challenges of identifying lymphoedema in patients with lipoedema using lymphoscintigraphy. Overdiagnosis of lymphoedema in this patient population is frequent and may result in reduced proposed surgical interventions. We retrospectively analyzed clinical data from patients followed for lipoedema, lymphoedema or lipolymphoedema and who underwent lymphoscintigraphy. All patients were assigned a clinical or lymphoscintigraphic diagnosis of lymphoedema and concordance between clinical and lymphoscintigraphic diagnosis was assessed. A modification of lymphoscintigraphic criteria interpretation was proposed to enhance the diagnosis specificity. We included 94 female patients (188 lower limbs). One hundred and thirty‐seven limbs presented with signs of lipoedema (137/188; 72.9%) and 42 with clinical signs of lymphoedema (42/188; 22.3%). Overall, 125 limbs presented with a diagnosis of lymphoedema on lymphoscintigraphy (125/188; 66.5%). Using lymphoscintigraphy to diagnose lymphoedema in patients with lipoedema resulted in low specificity (38.3%). By adjusting the interpretation criteria of the lymphoscintigraphic anomalies, we could achieve a specificity of 80.85%, reducing the risk of overdiagnosing lymphoedema in patients with lipoedema. This study contributes to the ongoing efforts to optimize the assessment and management of patients with lipoedema and potential lymphatic involvement, by modifying the interpretation of lymphoscintigraphic criteria.

Hadrien Amiel

Julien Coulie

Raphaël Georis

Raquel van la Parra

Genevieve Pirson

Christine Deconinck

Clinical Obesity

Clinical Obesity is an international peer-reviewed journal publishing high quality translational and clinical research papers and reviews focussing on obesity and its co-morbidities.    Key areas of interest are:    • Patient assessment, classification, diagnosis and prognosis  • Drug treatments, clinical trials and supporting research  • Bariatric surgery and follow-up issues  • Surgical approaches to remove body fat  • Pharmacological, dietary and behavioural approaches for weight loss  • Clinical physiology  • Clinically relevant epidemiology  • Psychological aspects of obesity  • Co-morbidities  • Nursing and care of patients with obesity.

Clinical Obesity is an international peer-reviewed journal that publishes high-quality translational and clinical research papers and reviews focusing on obesity and its comorbidities. Key areas of interest include: • Patient assessment, classification, diagnosis, and prognosis • Drug treatments, clinical trials, and supporting research • Bariatric surgery and follow-up issues • Surgical approaches to remove body fat • Pharmacological, dietary, and behavioral approaches for weight loss • Clinical physiology • Clinically relevant epidemiology • Psychological aspects of obesity • Comorbidities • Nursing and care of patients with obesity.

《Clinical Obesity》是一本国际同行评审的期刊，致力于发表高质量的转化医学和临床研究论文以及关于肥胖及其相关疾病的综述。期刊关注的主要领域包括：• 患者评估、分类、诊断和预后 • 药物治疗、临床试验及相关研究 • 减肥手术及其后续问题 • 移除体脂的外科方法 • 药物、饮食和行为干预的减重策略 • 临床生理学 • 相关流行病学 • 肥胖的心理学因素 • 相关疾病 • 肥胖患者的护理与照顾。

Enhancing lymphoscintigraphic specificity of lymphoedema diagnosis in patients with lipoedema

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Journal Info

Category	Quartile
ENDOCRINOLOGY & METABOLISM	3