Abstract Biomimicking organ phantoms with vivid biological structures and soft and slippery features are essential for in vitro biomedical applications yet remain hither to unmet challenges in their fabrication such as balancing between spatial structural complexity and matchable mechanical properties. Herein, 3D printable tissue‐mimicking elastomeric double network hydrogels with tailorable stiffness are evolved to idiosyncratically match diverse biological soft tissues by regulating the compositions of hydrogel matrix and the density of metal coordination bonds. Relying on digital light processing 3D printing, various mechanically tunable biomimetic volumetric hydrogel organ constructs with structural complexity and fidelity, including kidney, brain, heart, liver, stomach, lung, trachea, intestine, and even the intricate vascularized tissues, are fabricated faultlessly. Proof‐of‐concept 3D printed hydrogel heart and liver phantoms provide sophisticated internal channels and cavity structures and external realistic anatomical architectures that more closely mimic native organs. For the in vitro application demonstration, a 3D printed hydrogel brain phantom with tortuous cerebral arteries and slippery characters serves as an effective neurosurgical training platform for realistic simulation of endovascular interventions. This platform offers a means to construct mechanically precisely tunable hydrogel‐based biomimetic organ phantoms that are expected to be used in surgical training, medical device testing, and organs‐on‐chips.

Desheng Liu

Pan Jiang

Yixian Wang

Yaozhong Lu

Jiayu Wu

Xin Xu

Zhongying Ji

Chufeng Sun

Xiaolong Wang

Weimin Liu

Advanced Functional Materials

作为顶级材料科学期刊，ADVANCED FUNCTIONAL MATERIALS 每周报道材料科学各个方面的突破性研究，包括纳米技术、化学、物理和生物学。ADVANCED FUNCTIONAL MATERIALS 以其快速和公平的同行评审、质量而闻名内容丰富，影响力大，成为国际材料科学界的首选。主题：材料科学、纳米技术、液晶、半导体、超导体、光学、激光、传感器、多孔材料、发光材料、陶瓷、生物材料、磁性材料、薄膜、胶体、先进、材料、能源材料。

Advanced Functional Materials is a leading journal in materials science that publishes groundbreaking research across various aspects of the field on a weekly basis, including nanotechnology, chemistry, physics, and biology. Renowned for its rapid and fair peer review process and high-quality content, it has become the preferred choice in the international materials science community. Key topics covered include materials science, nanotechnology, liquid crystals, semiconductors, superconductors, optics, lasers, sensors, porous materials, luminescent materials, ceramics, biomaterials, magnetic materials, thin films, colloids, advanced materials, and energy materials.

《Advanced Functional Materials》是顶尖的材料科学期刊，每周报道材料科学领域的最新突破，包括纳米技术、化学、物理和生物学等方面。该期刊以其快速而公正的同行评审和高质量的内容而闻名，成为国际材料科学界的首选。主要主题包括：材料科学、纳米技术、液晶、半导体、超导体、光学、激光、传感器、多孔材料、发光材料、陶瓷、生物材料、磁性材料、薄膜、胶体、先进材料和能源材料。

Engineering Tridimensional Hydrogel Tissue and Organ Phantoms with Tunable Springiness

3D printable tissue‐mimicking elastomeric double network hydrogels with tailorable stiffness are evolved to idiosyncratically match diverse biological soft tissues by regulating the compositions of hydrogel matrix and the density of metal coordination bonds.

Category	Quartile
材料科学	1
材料科学, 化学综合	1
材料科学, 物理化学	1
材料科学, 材料科学综合	1
材料科学, 纳米科技	1
材料科学, 物理应用	1
材料科学, 物理凝聚态物理	1

Engineering Tridimensional Hydrogel Tissue and Organ Phantoms with Tunable Springiness

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Journal Info

Category	Quartile
PHYSICS, CONDENSED MATTER	1