A photocrosslinkable gelatin methacryloyl (GelMA) hydrogel has been widely examined in regenerative engineering because of its good cell–tissue affinity and degradability in the presence of matrix metalloproteinases. A halloysite aluminosilicate nanotube (HNT) is a known reservoir for the loading and sustained delivery of therapeutics. Here, we formulate injectable chlorhexidine (CHX)-loaded nanotube-modified GelMA hydrogel that is cytocompatible and biodegradable and provides sustained release of CHX for infection ablation while displaying good biocompatibility. The effects of HNTs and CHX on hydrogel degradability and mechanical properties, as well as on the kinetics of CHX release, and on the antimicrobial efficacy against oral pathogens were systematically assessed. Cytocompatibility in stem cells from human exfoliated deciduous teeth and inflammatory response in vivo using a subcutaneous rat model were determined. Our hydrogel system, that is, (CHX)-loaded nanotube-modified GelMA showed minimum localized inflammatory responses, supporting its ability for drug delivery applications. Moreover, we showed that the incorporation of CHX-loaded nanotubes reduces the mechanical properties, increases the swelling ratio, and diminishes the degradation rate of the hydrogels. Importantly, the presence of CHX-loaded nanotubes inhibits bacterial growth with minimal cell toxicity. Our findings provide a new strategy to modify GelMA hydrogel with chlorhexidine-loaded nanotubes for clinical use as an injectable drug delivery strategy for dental infection ablation.

Juliana S. Ribeiro

Ester A. F. Bordini

Jessica A. Ferreira

Ling Mei

Nileshkumar Dubey

J. Christopher Fenno

Evandro Piva

Rafael G. Lund

Anna Schwendeman

Marco C. Bottino

ACS Applied Materials & Interfaces

ACS APPLIED MATERIALS & INTERFACES 是一本面向化学家、工程师、物理学家和生物学家的跨学科社区的新出版物，重点关注如何开发新发现的材料和界面过程并将其用于特定应用。该杂志除了发表致力于推进应用材料研究的评论和论坛外，还发表来自学术界和工业界研究人员的完整文章和信件。

ACS Applied Materials and Interfaces is an interdisciplinary journal aimed at chemists, engineers, physicists, and biologists, focusing on the development of newly discovered materials and interface processes for specific applications. The journal publishes not only reviews and forums that advance applied materials research but also full articles and letters from researchers in academia and industry.

《ACS Applied Materials and Interfaces》是一本面向化学家、工程师、物理学家和生物学家的跨学科期刊，专注于新材料和界面过程的开发及其特定应用。该杂志不仅发表推动应用材料研究的评论和论坛，还刊登来自学术界和工业界研究人员的完整文章和信件。

ACS Applied Materials and Interfaces

Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation

This work forms injectable chlorhexidine-loaded nanotube-modified GelMA hydrogel that is cytocompatible, biodegradable, provides sustained release of CHX for infection ablation while displaying good biocompatibility and shows minimum localized inflammatory responses, supporting its ability for drug delivery applications.

Category	Quartile
材料科学	2
材料科学, 材料科学综合	2
材料科学, 纳米科技	2

Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation

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Journal Info

Category	Quartile
NANOSCIENCE & NANOTECHNOLOGY	1