Posttranslational histone modifications define chromatin structure and function. In recent years, a number of studies have characterized many of the enzymatic activities and diverse regulatory components required for monomethylation of histone H3 lysine 4 (H3K4me1) and the expression of specific genes. The challenge now is to understand how this specific chemical modification is written and the Set7 methyltransferase has emerged as a key regulatory enzyme mediating methylation of lysine residues of histone and non-histone proteins. In this review, we comprehensively explore the regulatory proteins modified by Set7 and highlight mechanisms of specific co-recruitment of the enzyme to activating promoters. With a focus on signaling and transcriptional control in disease we discuss recent experimental data emphasizing specific components of diverse regulatory complexes that mediate chromatin modification and reinterpretation of Set7-mediated gene expression.

Samuel Keating

Assam El-Osta

Epigenetics

EPIGENETICS 发表经过同行评审的原创研究和评论文章，提供了一个前所未有的论坛，可以揭示、共享和讨论表观遗传机制及其在不同生物过程中的作用。表观遗传学研究研究由除 DNA 序列修饰以外的机制引起的基因表达的可遗传变化。因此，表观遗传学在各种生物系统、疾病和学科中发挥着关键作用。感兴趣的主题包括（但不限于）：DNA甲基化核小体定位和修饰基因沉默印记核重编程染色质重塑非编码RNA非组蛋白染色体元件剂量补偿核组织表观遗传治疗和诊断营养和环境表观遗传学癌症表观遗传学神经表观遗传学

The journal "Epigenetics" publishes peer-reviewed original research and review articles, providing an unprecedented forum to reveal, share, and discuss epigenetic mechanisms and their roles in various biological processes. Epigenetic research focuses on heritable changes in gene expression caused by mechanisms other than DNA sequence modifications. Therefore, epigenetics plays a crucial role in various biological systems, diseases, and disciplines. Topics of interest include (but are not limited to): DNA methylation, nucleosome positioning and modification, gene silencing, imprinting, nuclear reprogramming, chromatin remodeling, non-coding RNA, non-histone chromosomal elements, dosage compensation, nuclear organization, epigenetic therapy and diagnostics, nutritional and environmental epigenetics, cancer epigenetics, and neuroepigenetics.

《Epigenetics》期刊发表经过同行评审的原创研究和评论文章，提供了一个前所未有的论坛，以揭示、共享和讨论表观遗传机制及其在不同生物过程中的作用。表观遗传学研究关注的是由除DNA序列修饰以外的机制引起的基因表达的可遗传变化。因此，表观遗传学在各种生物系统、疾病和学科中发挥着关键作用。感兴趣的主题包括（但不限于）：DNA甲基化、核小体定位和修饰、基因沉默、印记、核重编程、染色质重塑、非编码RNA、非组蛋白、染色体元件、剂量补偿、核组织、表观遗传治疗和诊断、营养和环境表观遗传学、癌症表观遗传学、神经表观遗传学。

Transcriptional regulation by the Set7 lysine methyltransferase

This review comprehensively explore the regulatory proteins modified by Set7 and highlight mechanisms of specific co-recruitment of the enzyme to activating promoters and recent experimental data emphasizing specific components of diverse regulatory complexes that mediate chromatin modification and reinterpretation of Set7-mediated gene expression.

Category	Quartile
生物学	3
生物学, 生化与分子生物学	3
生物学, 遗传学	3

Transcriptional regulation by the Set7 lysine methyltransferase

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Journal Info

Category	Quartile
GENETICS & HEREDITY	2