Despite the recent introduction of new effective systemic agents, the survival of patients with hepatocellular carcinoma (HCC) at advanced stages remains dismal. This underscores the need for new therapies, which has spurred extensive research on the identification of the main drivers of pathway de-regulation as a source of novel therapeutic targets. Frequently altered pathways in HCC involve growth factor receptors (e.g., VEGFR, FGFR, TGFA, EGFR, IGFR) and/or its cytoplasmic intermediates (e.g., PI3K-AKT-mTOR, RAF/ERK/MAPK) as well as key pathways in cell differentiation (e.g., Wnt/β-catenin, JAK/STAT, Hippo, Hedgehog, Notch). Somatic mutations, chromosomal aberrations and epigenetic changes are common mechanisms for pathway deregulation in HCC. Aberrant pathway activation has also been explored as a biomarker to predict response to specific therapies, but currently, these strategies are not implemented when deciding systemic therapies in HCC patients. Beyond the well-established molecular cascades, there are numerous emerging signaling pathways also deregulated in HCC (e.g., tumor microenvironment, non-coding RNA, intestinal microbiota), which have opened new avenues for therapeutic exploration.

Teresa Garcia-Lezana

Juan Luis Lopez-Canovas

Augusto Villanueva

Advances in cancer research

癌症研究进展 (ACR) 涵盖了一段非凡的发现时期，其中包括生物学革命的开始。癌症研究进展 (ACR) 涵盖了一段非凡的发现时期，其中包括生物学革命的开始。第一本 ACR 卷出版于 WATSON 和 CRICK 报道生物学中心法则 DNA 双螺旋的那一年。在前 100 卷中，发现了一些帮助塑造这场革命的人的许多贡献，他们在癌症研究中取得了许多显着的发现，并由此发展而来。

Advances in Cancer Research covers significant advancements in the field of cancer research, marking the beginning of a biological revolution. The first volume was published in the same year that Watson and Crick reported the double helix structure of DNA. In the first 100 volumes, numerous contributions from scientists who shaped this revolution led to significant discoveries in cancer research, driving the development of the field.

《Advances in Cancer Research》涵盖了癌症研究领域的重大进展，标志着生物学革命的开端。第一卷的出版恰逢沃森和克里克报道DNA双螺旋结构的那一年。在前100卷中，许多为这场革命做出贡献的科学家们在癌症研究中取得了显著的发现，这些发现推动了该领域的发展。

Advances in Cancer Research

Adv Cancer Res

Signaling pathways in hepatocellular carcinoma.

Beyond the well-established molecular cascades, there are numerous emerging signaling pathways also deregulated in HCC (e.g., tumor microenvironment, non-coding RNA, intestinal microbiota), which have opened new avenues for therapeutic exploration.

Category	Quartile
医学	2
医学, 肿瘤学	3

Signaling pathways in hepatocellular carcinoma.

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info