Obesity is one of the worldwide prevalent disease caused by the imbalance between food intake and energy expenditure. Over a 100 years of research demonstrate that hypothalamus is the critical brain region regulating energy homeostasis, and evidences suggest the participation of non-neuronal populations such as astrocytes and microglia in the regulation of energy homeostasis. Recently, fat-rich diet induced hypothalamic inflammation has been found to deregulate the energy homeostasis, leading to the insulin resistance, glucose intolerance, and obesity. Several underlying mechanisms have been proposed, yet compelling evidences require further elucidations. This review discusses the up to date proposed mechanisms by which fat-rich diet induces hypothalamic inflammation and obesity.

Jichang Seong

Jung Yun Kang

Ji Su Sun

Ki Woo Kim

Archives of pharmacal research

ARCHIVES OF PHARMACAL RESEARCH 是韩国药学会的官方期刊，自 1976 年开始出版。ARCHIVES OF PHARMACAL RESEARCH 是一本跨学科期刊，致力于发表药物发现、药物开发、和药物行动，以提供关于药物和候选药物的基本和新颖的信息。

The Archives of Pharmacal Research is the official journal of the Korean Pharmaceutical Society, published since 1976. This interdisciplinary journal focuses on research in drug discovery, drug development, and drug action, aiming to provide fundamental and novel information about drugs and drug candidates.

《Archives of Pharmacal Research》是韩国药学会的官方期刊，自1976年开始出版。该期刊是一份跨学科的学术刊物，专注于药物发现、药物开发和药物作用的研究，旨在提供关于药物及其候选药物的基础和新颖的信息。

Archives of Pharmacal Research

Arch Pharm Res

Hypothalamic inflammation and obesity: a mechanistic review.

This review discusses the up to date proposed mechanisms by which fat-rich diet induces hypothalamic inflammation and obesity.

Category	Quartile
医学	3
医学, 药学	2
医学, 药物化学	3

Hypothalamic inflammation and obesity: a mechanistic review.

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	1