Acta Orthopaedica Scandinavica

"Prevention of chronic entrapment of the ring finger flexor profundus muscle in ulnar shaft fractures in children – a case report." Acta Orthopaedica Scandinavica, 75(4), pp. 503–504

David Hendel

Prevention of chronic entrapment of the ring finger flexor profundus muscle in ulnar shaft fractures in children – a case report

儿童尺骨骨干骨折中环指深屈肌慢性卡压的预防——病例报告

Background The aim of this study was to develop an experimental model that allows to elude the potential role of the preexisting graft microvasculature for vascularization and mineralization of osteochondral grafts.Animals and methods For that purpose, the II-IV metatarsals of fetal DDY-mice known to be nonvascularized at day 16 of gestation (M16) but vascularized at day 18 (M18) were freshly transplanted into dorsal skin fold chambers of adult DDY mice. Using intravital microscopy angiogenesis, leukocyte-endothelium interaction and mineralization were assessed for 12 days.Results Angiogenesis occurred at 32 hours in M18, but not before 57 hours in M16 (p = 0.002), with perfusion of these vessels at 42 hours (p = 0.005) and 65 hours (p = 0.1), respectively. Vessels reached a density three times as high as that of the recipient site at day 6, remaining constant until day 12 in M18, whereas in M16 vascular density increased from day 6 and reached that of M18 at day 12 (p = 0.04). Leukocyte-endothelium interaction showed sticker counts elevated by a factor of 4-5 in M18 as compared to M16. Mineralization of osteochondral grafts did not differ between M16 and M18, which significantly increased in both groups throughout the observation period.Interpretation We propose the faster kinetics in the angiogenic response to M18 and the elevated counts of sticking leukocytes to rest on the potential of establishing end-to-end anastomoses (inosculation) of the vascularized graft with recipient vessels.

Dominique Rothenfluh

Thomas Demhartner

Christian Fraitzl

Marco Cecchini

Reinhold Ganz

Michael Leunig

Potential role of pre-existing blood vessels for vascularization and mineralization of osteochondral graftsAn intravital microscopic study in mice

预先存在的血管在骨软骨移植血管化和矿化中的潜在作用：小鼠活体显微镜研究

In a monocentric, randomized, placebo-controlled double-blind study, we investigated the efficacy of two doses of diclofenac-cholestyramine for the prevention of heterotopic ossification (HO).The study comprised 245 patients undergoing total hip arthroplasty (THA).With 150 mg cholestyramine-bound diclofenac (2 x 1 capsule Voltaren resinate) daily during a postoperative period of 14 days, 19% of patients showed slight HO (Brooker grade 1), and no patient had more severe ossifications (grades 2-4). In the group receiving 75 mg daily (1 x 1 capsule), 17% of patients showed grade 1 HO and 4% grade 2 HO. No patient had grades 3-4 HO. No differences in clinical results were seen between the two groups 6 months after THA.Since the rate of adverse gastrointestinal events was lower (23% versus 38%, p = 0.02) in the group receiving the lower dose, we recommend it.

Stefan Sell

Oliver Phillips

Martin Handel

No difference between two doses of diclofenac in prophylaxis of heterotopic ossifications after total hip arthroplasty

双氯芬酸两种剂量在全髋关节置换术后异位骨化预防中无差异

Background The need for safe bone allografts is increasing and preservation of femoral heads from patients being operated on with hip arthroplasty should be encouraged. However, should we preserve femoral heads from patients operated on for neck fracture as tissue mechanical quality may not be satisfactory?Material and methods We compared the evolution of stiffness and compactness of fresh-frozen morselized bone obtained from osteoarthrotic femoral heads and those from neck fractures. Both materials were also compared after freeze-drying and irradiation. We used 6 osteoarthrotic and 6 neck-fracture femoral heads to prepare 4 batches of morselized bone. 18 samples from each batch were impacted in a contained cylinder. Frozen bone grafts were tested after thawing at room temperature for 2 hours and freeze-dried grafts were tested after 30 minutes of rehydration.Results The stiffness of fresh-frozen neck fracture bone was lower than that of fresh-frozen osteoarthrotic bone at 150 impactions. The stiffness of freeze-dried irradiated bone was higher than that of the fresh-frozen bone and did not differ between osteoarthrotic and neck-fracture bone.Interpretation Solvent-treated freeze-dried bone from femoral heads procured during arthroplasty for sub-capital hip fractures represents a valuable source of material for allografts, addressing concerns regarding serological testing, medical history and bone quality.

Olivier Cornu

Olivier Manil

Bernard Godts

Bénédicte Naets

John Van Tomme

Christian Delloye

Xavier Banse

Neck fracture femoral heads for impaction bone graftingEvolution of stiffness and compactness during impaction of osteo-arthrotic and neck-fracture femoral heads

颈骨折股骨头用于压配骨移植的刚度和致密性演变：骨关节炎和颈骨折股骨头压配过程中的变化

Background Polymorphonuclear neutrophils (PMN) are the first cells to take part in the local foreign body reaction in aseptic loosening of endoprostheses. The aim of this study was to evaluate the systemic host reaction to total joint replacement by measuring the production of nitric oxide by neutrophils before and after total joint replacement.Patients and method Blood samples were collected from 33 patients (27 hips and 6 knees) before surgery, and 2 weeks, 2 months and 2.5–3 years after surgery. The levels of nitric oxide produced by PMN were measured by the method described by Markert et al. (1994).Results Patients reporting pain in the region of the implant 3 years after surgery, and also patients with radiographic signs of loosening, had higher production of NO in the early period and 3 years after the implantation than those with good clinical results.Interpretation We propose that elevated levels of nitric oxide production by PMNs may serve as a marker of total joint prosthesis loosening.

出版信息	出版商: Taylor and Francis Ltd.，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 1971，原创研究文献占比: ，自引率:， Gold OA占比:

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Prevention of chronic entrapment of the ring finger flexor profundus muscle in ulnar shaft fractures in children – a case report

Potential role of pre-existing blood vessels for vascularization and mineralization of osteochondral graftsAn intravital microscopic study in mice

No difference between two doses of diclofenac in prophylaxis of heterotopic ossifications after total hip arthroplasty

Neck fracture femoral heads for impaction bone graftingEvolution of stiffness and compactness during impaction of osteo-arthrotic and neck-fracture femoral heads

Neutrophils are active in total joint implant loosening

The Dutch Orthopaedic Association has joined the Nordic Orthopedic Federation

Prevention of chronic entrapment of the ring finger flexor profundus muscle in ulnar shaft fractures in children – a case report

Potential role of pre-existing blood vessels for vascularization and mineralization of osteochondral graftsAn intravital microscopic study in mice

No difference between two doses of diclofenac in prophylaxis of heterotopic ossifications after total hip arthroplasty

Neck fracture femoral heads for impaction bone graftingEvolution of stiffness and compactness during impaction of osteo-arthrotic and neck-fracture femoral heads