Acta Pharmaceutica Hungarica

The rapid dispersion of COVID-19 occurred after the two large religious gatherings in Malaysia. To restrain the transmission of COVID-19 the government of Malaysia recommended using face masks with physical distancing, using hand wash and executing several confinement periods. This study aimed to assess the changing mindset of Malaysians about face masks through a hypothetico-deductive technique with the combination of the theory of Planned Behavior. We also used five-point-Likert scale ranging 1-5. The majority of respondents firmly concurred that it was a good idea (mean = 4.80) to start wearing a face mask. Additionally, they have a tendency to wear masks (mean = 4.84) and request that their loved ones (mean = 4.74), family members (mean = 4.79) and friends (mean = 4.76) do the same. Respondents believe that they have a moral obligation to wear a face mask when they go out. The majority understood the advantages of wearing face masks (mean = 4.70), had a favorable opinion (mean = 4.69) and felt morally obligated (mean = 4.69) to do so. This statement was supported by our inter-item correlation. The respondents thought wearing a face mask during the COVID-19 confinement period was beneficial and reduce the possibility of COVID-19 infection; it increased their positive perception (61.6%) and their tendency (56.9%) to wear a face mask while their moral obligation to wear a mask (53.9%) also increased. The outcomes of this study may support health policymakers to formulate a suitable guideline on what to do if such a pandemic occurs again in the future.

Najmus Sayadat Pitol

Ana Shakirah Sapir

Attitudes toward mask wearing in Malaysia during the COVID pandemic

马来西亚在新冠疫情期间对戴口罩的态度

Aims: The purpose of our study was to conduct a phytochemical analysis of Rhaponticum carthamoides in order to gain a better understanding of its chemical profile and the active constituents responsible for its bioactivities. Methods: The methanolic extract of the root was fractionated using multiple chromatographic methods, including normal, medium and high-pressure chromatography, rotation planar chromatography with a variety of stationary phases and eluents. The structures of the isolated compounds were identified by comparing their NMR spectra with those reported in the literature. Results: As a result of our experiments, the mixture of cis and trans isomers of tiophene derivatives, vanillic acid, chloro-genic acid methyl ester, ajugasterone C, makisterone C, tachioside, 20-hydroxyecdysone, 24-epi-makisterone A and evofo-lin B were isolated and identified in the root of the plant. Conclusion: Tachioside, evofolin B and chlorogenic acid methyl ester have been reported for the first time from this species.

Zoltán Péter Zomborszki

Norbert Kúsz

Judit Hohmann

Dezső Csupor

Three novel constituents from the roots of Rhaponticum carthamoides

来自岩风根的三种新成分

Background: The increasing distribution of Substandard and Falsified Medical Products is a well-known health risk. The quantity of these medicines sent to consumers is not known, and it can only be accurately estimated with a specific sample collection study. These consignments ordered via mail from illegal online sources pose a great health risk on the population. Methods: We used an observation-based cross-sectional study in order to obtain accurate data regarding the number of medicinal shipments from dubious origin. We collected data on-site to assess the number of Substandard and Falsified Medical Products arrived in Hungary via postal services in 2020. Results: The therapeutic category (according to the Anatomical Therapeutic Chemical Classification (ATC) system of the WHO) of the most frequently shipped products contained active ingredients for treating erectile dysfunction. These substances were sildenafil (G04BE03), tadalafil (G04BE08), and other analgesics and antipyretics, such as anilides (N02BE). In 2020 we estimated that the real Defined Daily Dose of SFMP was 1.2 DDD per 1000 inhabitants per day. This value is equivalent to one third of Hungary’s opioid analgesic use. We also calculated that the average exposure was approximately 4 ampoules per day and 40 oral preparations per day (without DDD value) for 1000 people in Hungary. Conclusions: This study accurately estimates the number of consignments received by post containing Substandard and Falsified Medical Products, and determines the quantity per 1000 persons per day expressed in DDD. This parameter may be used as a benchmark that helps more detailed research in the future.

Péter Vajda

Eszter Ábrahám

Zsolt Bodrogi

Tímea Dergez

András Fittler

Róbert György Vida

Lajos Botz

Estimating the quantity of substandard and falsified medical products purchased online

估计在线购买的劣质和假冒医疗产品的数量

Nasal delivery of drugs may substitute the parenteral or oral administration. Among the nasal drug delivery systems, powders have favourable properties such as their good adhesion to the mucosa or their improved stability due to their low moisture content. In this work, two cyclodextrin-based meloxicam potassium-containing nasal powder formulations were tested applying the accelerated stability test conditions according to the ICH guideline. Based on the results, the hydroxypropyl- β-cyclodextrin containing sample showed better stability, however, the experienced morphological change is a problem to be solved.

Patrícia Varga

Csilla Balla-Bartos

Rita Ambrus

Stability testing of cyclodextrin-based meloxicam potassium containing nanospheres intended for nasal administration

基于环糊精的美洛昔康钾纳米球鼻腔给药稳定性测试

CoViD-19 used the Angiotensin-converting enzyme 2 (ACE2) receptors for cell entry. ACE inhibitors (ACEi) and angiotensin ii receptor type 2 blockers (Arbs) are one of the medications used in CoViD-19 patients. Some studies suggested that both of them may increase the virulence of CoViD-19.Objectives: The study aimed to determine whether the clinical condition of ACEI/ARB users is significantly different from non-ACEi/Arb users or not. Methods: in this cross-sectional study, 671 patients who were recognized by rT-PCr participated in the study. ACEis/Arb users in these positive participants were 175 (26%). All of them had been using ACEs/Arbs before got CoViD-19. Demographic, clinical, and paraclinical data were collected through medical records and laboratory results.Results: Our analysis demonstrated that both groups did not differ significantly interms of death (p value=0.12). The prevalence of severe clinical course was significantly higher than non-ACEIs/ARBs users. However, we matched both groups in terms of gender and age. Surprisingly, it represented ACEis/Arb users had no more chance to experience a severe clinical course [p=0.35, OR=1.22, CI (0.79, 1.87)]. Moreover, the mean ejection fraction (EF) was higher in them (51.6 ± 8.3, p&lt;0.001). Also, the frequency of CRP-positive patients was higher in them (73.1%, p=0.09). Other laboratory results (leukocytes and lymphocyte counts, LDH) were not significant.Conclusions: We could not find evidence that ACEI/ARBs treatment could be a risk factor for the severity of COVID-19. Thus, their treatment regime should not be altered for CoViD-19.

Erfan Kazemi

Salman Daliri

Reza Chaman

Marzieh Rohani-Rasaf

Ehsan Binesh

Hossein Sheibani

Relationship between angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) use with outcome and cardiovascular involvement in patients with COVID-19

血管紧张素转换酶抑制剂(ACEI)和血管紧张素受体阻滞剂(ARB)使用与COVID-19患者预后及心血管相关性的关系

Background: Various samples are taken from a deceased body for toxicological analysis, with the number of samples varying based on the individual's background, to determine the cause of death. The primary objective is to ascertain the connection between the toxicology findings from bile and other samples in determining the cause of death. Method: In a descriptive and cross-sectional study, two methods were utilized: high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS). Result and conclusion: The findings indicate that the toxicology results from bile were either similar to the other main samples or different. In a few cases, there were varied results that were not related to the cause of death. The study used highly sensitive analytical methods such as GC‒MS and HPLC, and qualitative results from toxicology labs in legal medicine. These results suggest that toxicology results from bile samples are not considered crucial in determining causes of death. They play a minor role and are typically only examined when blood samples are not available.

Sajjad Sadeghi

Sheis Amini

Toxicology results of bile samples: Are they valuable in determining the cause of death?

胆汁样本毒理学结果：它们在确定死亡原因方面有价值吗？

Aims: Pholiota populnea is an edible macrofungus, distributed worldwide wherever cottonwood occurs. This study aimed to explore the potential antimicrobial properties of isolated lanostane triterpenes from P. populnea, namely pholiols A-D, E, G, H, J, L, and Q. Methods: A diverse range of microorganisms, including Gram-negative, and Gram-positive bacterial and fungal strains were employed to assess the antimicrobial activity of these natural triterpenes. Results: Among the investigated compounds, pholiol C [3β-acetoxy-2α-(3-hydroxy-3-methylglutaroyloxy)-12β,25-dihydroxylanosta-8-en-24-one] exhibited significant activity against Gram-positive bacteria, with minimum inhibitory concentrations (MIC) of 100 µM against Streptococcus agalactiae, and 200 µM against Staphylococcus aureus, S. aureus MRSA, S. epidermidis, Enterococcus faecalis, and Bacillus subtilis. Additionally, pholiols G and E displayed notable inhibitory properties against the S. agalactiae strain, both exhibiting a MIC value of 200 µM. Conclusion: These findings underscore the potential of the mushroom P. populnea as a noteworthy source of triterpenes possessing antimicrobial activity.

Morteza Yazdani

Annamária Kincses

Lanostane Triterpenes with Antimicrobial Activity: A Study of the Pholiol Series from the Hungarian Edible Mushroom Pholiota populnea

抗菌作用的羊毛甾烷三萜类化合物：匈牙利食用蘑菇黄鳞伞属系列研究

出版信息	出版商: Magyar Gyogyszereszeti Tarsasag，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 1965，原创研究文献占比: ，自引率:， Gold OA占比:

Acta Pharmaceutica Hungarica

期刊引文格式

有 1 位以上作者的期刊

有 2 位作者的期刊

有 3 位作者的期刊

有 5 位以上作者的期刊

书籍引用格式

学位论文引用格式

网页引用格式

专利引用格式

手工熬夜修改参考文献？研飞自动匹配期刊，一键轻松成稿，支持 Word/WPS

投稿经验分享

Attitudes toward mask wearing in Malaysia during the COVID pandemic

Three novel constituents from the roots of Rhaponticum carthamoides

Estimating the quantity of substandard and falsified medical products purchased online

Stability testing of cyclodextrin-based meloxicam potassium containing nanospheres intended for nasal administration

Relationship between angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) use with outcome and cardiovascular involvement in patients with COVID-19

Toxicology results of bile samples: Are they valuable in determining the cause of death?

Lanostane Triterpenes with Antimicrobial Activity: A Study of the Pholiol Series from the Hungarian Edible Mushroom Pholiota populnea

Attitudes toward mask wearing in Malaysia during the COVID pandemic

Three novel constituents from the roots of Rhaponticum carthamoides

Estimating the quantity of substandard and falsified medical products purchased online