Acta rheumatologica Scandinavica

SummaryAlthough morphological and functional kidney lesions are well known to occur in rheumatoid arthritis (RA), there appear to be no previous reports on reversible acute renal failure. That interstitial nephritis plays a part in acute renal failure is clinically documented but the pathophysiology is obscure. The role of raised interstitial pressure has often been discussed but convincing evidence is still lacking.Two patients with classical RA complicated by reversible oliguria and impaired kidney function are presented. Renal biopsies revealed no glomerular, tubular or amyloid lesions. The only light microscopic finding was greatly increased interstitial edema, which stained metachromatically with toluidine blue and was hyaluronidase-sensitive.It is supposed that the abnormal concentration of interstitial hyaluronic acid and its high water-binding capacity leads to an increase of interstitial pressure, which is followed by renal insufficiency. The mucinous edema of the kidneys is assumed to be an acute reaction of the pathological connective tissue in general.

Otto Wegelius

Matti Klockars

Acta Rheumatologica Scandinavica

Reversible Acute Renal Failure Complicating Rheumatoid Arthritis

类风湿性关节炎并发可逆性急性肾衰竭

SummaryThe 7S and 19S distribution of blood group isoantibodies (isoagglutinins) has been measured in patients with systemic lupus erythematosus. The only possibly significant finding was a lower level of macroglobulin isoagglutinin to B cells in patients of blood type A. This is consistent with previous findings of lessened response to bacterial antigens by the macroglobulin antibody.

John Baum

7S and 19S Isoagglutinins in Systemic Lupus Erythematosus

系统性红斑狼疮中的7S和19S同种凝集素

Arthritis following certain Salmonella infections, dysentery, and non-specific enterocolitis exemplifies the fact that intestinal infections can elicit rheumatic reactions. Recent observations indicate that in the last-mentioned group specific microbes, such as Clostridium perfringens and Yersinia enterocolitica, may be involved. References are made to the findings of an abnormal intestinal flora, notably C. perfringens, in patients with chronic arthritis and of circulating and cell-bound antibodies to C. perfringens alphatoxin as evidence of an immunologic response to this microbe in rheumatoid disease.

Börje Olhagen

The Intestine and Rheumatism

肠道与风湿病

Summary85 muscles, in 30 rheumatoid arthritis patients, were examined by EMG. The patients were subdivided into steroid and non-steroid treated groups.In both groups, the EMG demonstrated myopathic, polymyositic and neuropathic lesions, the first two predominating. Similar changes were found regardless of the size of the muscle examined. A relatively high number of myopathic changes were observed in early RA. The activity of the disease did not seem to play an important role. No correlation with the condition of the adjacent joint was found. No patient had a normal EMG in all the muscles examined. The conduction velocity indicated an entrapment syndrome in four patients. Creatine phosphokinase was normal in 23 patients, while aldolase was moderately high in 9 of 23 cases.

A. Magora

E. Wolf

B. Gonen

Electrodiagnostic Investigation of the Neuromuscular Lesions in Rheumatoid Arthritis

类风湿关节炎神经肌肉病变的电诊断研究

SummaryThe muramidase activity of serum was studied in 27 cases of rheumatoid arthritis. The enzyme activity in rheumatoid serum (mean 11.0 μg./ml.) did not differ significantly from that in the 30 healthy controls (mean 9.4 μg./ml.). The muramidase activity in the synovial fluid of 36 rheumatoid arthritis patients was markedly elevated (mean 20.2 μg./ml.). In osteoarthritic synovial fluid (8 cases) the muramidase activity was low (mean 8.0 μg./ml.).No correlation was found between the total white blood count and the muramidase activity in rheumatoid synovial fluid. A positive relationship was observed between the enzyme activity and the total protein concentration. The elevated concentration of muramidase in synovial fluid of rheumatoid arthritis patients is interpreted as evidence of increased release of hydrolytic lysosomal enzymes. It remains to be shown which type of synovial fluid leukocytes produces the enzyme in question.

Martti Oka

Olavi Seppälä

Muramidase (Lysozyme) in Joint Fluid and Serum of Rheumatic Patients

风湿病患者关节液和血清中的溶菌酶（溶菌酶）

SummaryOne autopsy case of ankylosing spondylitis was studied with histology, tetracycline bone labelling, microradiography and scanning electron microscopy. A focus of inflammatory cells was found beneath the anterior periost of a lumbar vertebral body and early marginal syndesmophytes were demonstrated by histology and microradiography. Tetracycline bone labelling showed new bone formation within osteophytes attempting to bridge an intervertebral facet joint. Scanning electron microscopy showed degeneration of femoral head articular cartilage while articular cartilage of an unfused portion of a sacro-iliac joint showed no definite changes with respect to equivalent controls.

H. Inoue

H. Julkunen

K. Vainio

Ankylosing Spondylitis: Report of one Case Studied with Histology, Tetracycline Bone Labelling, Microradiography and Scanning Electron Microscopy

强直性脊柱炎：一例病例研究，涉及组织学、四环素骨标记、显微放射摄影和扫描电子显微镜观察

SummaryThe effects of two steroid preparations (Hydrocortone and Celestona Bifas) on the acid and alkaline phosphatase levels in the synovial fluids were studied in patients with rheumatoid arthritis. One knee joint was treated with steroid and the effects on the enzyme levels were followed in both the treated and the contralateral untreated joint. Significant decrease of both acid and alkaline phosphatase was found in joints treated with Hydrocortone. No significant effect was observed for Celestona Bifas. The results suggest that the effects of Hydrocortone on acid and alkaline phosphatase were due to different mechanisms.

R. K. Lemperg

G. N. M. Beckman

L. E. A. Beckman

Effect of Intraarticular Corticosteroid Administration on Acid and Alkaline Phosphatase Activity in Synovial Fluid of Patients with Rheumatoid Arthritis

关节内皮质类固醇注射对类风湿关节炎患者滑液中酸性和碱性磷酸酶活性的影响

Veikko L. Laine

From the editor

来自编辑

SummaryThe radiographic appearance of the pubic symphysis was studied in 158 normal subjects of varying age and in 67 and 22 cases of RA and ankylosing spondylitis, respectively. The pubic symphysis undergoes significant anatomical changes during post-adolescent life. In old age changes typical of osteoarthritic deformation are seen. Small local erosions are significantly more frequent in RA patients than in the normal population. Changes in ankylosing spondylitis tend to be more extensive and easily visible than in RA. Tomographic studies suggest that minor changes typical of RA are often not revealed by ordinary radiography, owing to the peculiar anatomical features of the symphysis.

Martti Kormano

Radiographic Appearance of the Pubic Symphysis in Old Age and in Rheumatoid Arthritis

老年及类风湿性关节炎中耻骨联合的放射学表现

SummaryThe MBF in the tibial muscle of RA patients was studied by a Xe-133 clearance method. The MBF, both at rest and after muscular ischemia, was significantly reduced in RA. The decrease in MBF was not clearly dependent on swelling of the neighbouring joints in the extremity studied. The RA patients showed a greater increase in MBF after muscular ischemia than the controls.No correlation was observed between MBF at rest and the ESR, Waaler-Rose titer, duration of the disease and age. In fresh hemiplegic cases there was no clear difference in MBF between the involved and contralateral extremity.The following conclusions were drawn: 1. The reduced MBF in RA reflects the changes in the muscular microcirculation; 2. The central nervous system plays no major role in the development of the diminished MBF in RA.

Ahti Rekonen

Irma Elomaa

Muscle Blood Flow in Rheumatoid Arthritis

类风湿性关节炎中的肌肉血流

Publication Information	Publisher: Steinviks Bokforlag，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1955，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Acta rheumatologica Scandinavica

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