Alcoholism and Psychiatry Research

Epidemiologic evidence has been presented over the last 10 to 15 years, that the process of gastric carcinogenesis is directly correlated with alimentary habits. The first suggestion of the importance of environmental factors in the induction of gastric tumors was provided by the observation of a large variability in tumor incidence among different countries or areas that could not be explained by racial differences (American Cancer Society, 1982). Haenszel, Correa (1978), Wynder, Hiryama (1977) and McMichael (1980), reported changes in incidence for migrants from Japan via Hawaii to the mainland United States; from Eastern and Northern Europe to the United States and Canada; and from Europe generally to Australia. Migrants from any part of the world with a low tumor incidence such as Poland, South America, Japan, or southern Europe to regions with a higher risk such as the Anglo-Saxon countries, show a rapid increase in the tumor incidence.

R. Cardin

M. Zordan

F. Farinati

R. Naccarato

A. G. Levis

Alcoholism

Activation by Human Gastric Mucosa of Alimentary Procarcinogens

人胃黏膜激活膳食致癌物

Acetaldehyde, a product of ethanol metabolism, has been implicated in a number of adverse effects of ethanol (Lieber, 1988). A major reason for acetaldehyde toxicity may be its ability to form covalent adducts with various proteins and cell constituents. The primary site of acetaldehyde adduct formation should be the liver, where it is believed to inhibit microtubule assembly, decrease enzyme activities and increase protein catabolism (Sorrell and Tuma, 1987; Lieber, 1988). Recent findings indicating that acetaldehyde binding with proteins can also trigger immune responses have provided the basis for antibody-based detection of acetaldehyde condensates as biological markers of excessive alcohol consumption (Israel et al., 1986, 1988; Lin et al., 1988). The present contribution summarizes recent studies on the formation of acetaldehyde-protein adducts as a result of alcohol consumption and suggests a possible association of adduct formation with hepatic fibrogenesis. For more detailed accounts and references on the immunological and functional aspects of acetaldehyde-protein binding the reader is referred to Israel et al. (1988) and Sorrell and Tuma (1987), respectively. Acetaldehyde-promoted fibrogenesis has been discussed in greater depth by Lieber (1988).

Onni Niemelä

Acetaldehyde Adducts and Excessive Alcohol Consumption

乙醛加合物与过量饮酒

Cell proliferation is an important measure and characteristic of tissues. Its evaluation must be quantitative as well as morpological, relating proliferative activity to histological structure. Cell proliferation is dynamic, measurement of it should include time, moreover it can even change with time. Therefore, one time point measurements are always equivocal, and even observations over time must neglect acceleration or slowing of proliferative activity, unless experiments are tremendous laborious with multiple time point observations.

Ulrich A. Simanowski

Burkhard Kommerell

Helmut K. Seitz

Effect of Ethanol on Gastrointestinal Cell Proliferation

乙醇对胃肠细胞增殖的影响

Constance Weisner

Overview

概述

Standardized economic evaluation instruments are an important tool in the analysis of change and performance of addiction treatment. Nevertheless, compared to other health care sectors, economic evaluation of addiction treatment is still rare. The present paper proposes two comprehensive economic evaluation instruments that are methodologically sound and that meet the objectives of comprehensiveness, standardization, and comparability. The Drug Abuse Treatment Cost Analysis Program (DATCAP) can be used to estimate the economic cost of treatment services; the Drug Abuse Treatment Financing Analysis Program (DATFin) is a companion instrument and analyzes the complexity and change of treatment financing. This paper outlines the contents of each instrument and, for illustrative purposes, presents results from several case studies. Suggestions for updates and enhancements for each instrument are also discussed.

Helena J. Salomé

Michael T. French

Using Cost and Financing Instruments for Economic Evaluation of Substance Abuse Treatment Services

使用成本和融资工具进行物质滥用治疗服务经济评估

E Fernández Felgueroso

I Torcida Valiente

B Rodero Vicente

Rev Sanid Hig Publica (Madr)

Alcoholism and Society

酒精中毒与社会

Over 3,000 patients from 15 VA inpatient, substance abuse treatment programs showed considerable improvement from intake to a one-year follow-up. Patients in 12-step programs, as opposed to cognitive-behavioral (CB) or eclectic programs, and those with more extended continuing outpatient mental health care and 12-step self-help group involvement, were more likely to be abstinent and free of substance use problems at follow-up. Consistent with their better one-year outcomes, patients in 12-step programs improved more between intake and discharge than CB patients on proximal outcomes assumed to be specific to 12-step treatment (e.g., disease model beliefs) and as much or more on CB proximal outcomes. Proximal outcomes assessed at treatment discharge and follow-up were, at best, modestly related to one-year substance use and other outcomes. No evidence was found that CB or 12-step treatment is more beneficial for certain types of patients.

Publication Information	Publisher: Univerisity Department of Psychiatry University Hospital Center Sestre milosrdnice，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2015，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Alcoholism and Psychiatry Research

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Activation by Human Gastric Mucosa of Alimentary Procarcinogens

Acetaldehyde Adducts and Excessive Alcohol Consumption

Effect of Ethanol on Gastrointestinal Cell Proliferation

Overview

Using Cost and Financing Instruments for Economic Evaluation of Substance Abuse Treatment Services

Alcoholism and Society

Overview

Using Cost and Financing Instruments for Economic Evaluation of Substance Abuse Treatment Services

A Comparative, Process-Effectiveness Evaluation of VA Substance Abuse Treatment

Access to Substance Abuse Services in Rural Areas