DIGESTIVE DISEASES AND SCIENCES 发表高质量的、经过同行评审的原创论文，涉及胃肠病学、肝病学和相关领域的基础/转化和临床研究。这本插图精美的期刊全面报道了基础病理生理学、新技术进步和临床突破；著名院士和从业者对新的科学发展和实际医学问题的见解；讨论重点关注当地和全球社会、经济和政府政策的最新变化，这些变化会影响胃肠病学和肝病学学科内的护理服务。

The American Journal of Digestive Diseases publishes high-quality, peer-reviewed original research articles covering basic, translational, and clinical studies in gastroenterology, hepatology, and related fields. This beautifully illustrated journal comprehensively reports on fundamental pathophysiology, advancements in new technologies, and clinical breakthroughs; insights from renowned scholars and practitioners on new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and global social, economic, and governmental policies that impact the delivery of care in gastroenterology and hepatology.

《American Journal of Digestive Diseases》发表高质量、经过同行评审的原创论文，涵盖胃肠病学、肝病学及相关领域的基础、转化和临床研究。该期刊插图精美，全面报道基础病理生理学、新技术进展和临床突破；著名院士和从业者对新的科学发展及实际医学问题的见解；讨论重点关注当地和全球社会、经济和政府政策的最新变化，这些变化将影响胃肠病学和肝病学领域的护理服务。

American Journal of Digestive Diseases

Pyruvate kinase M2 (PKM2), a key glycolytic enzyme, is involved in multiple cellular processes including apoptosis. Recently increased fecal PKM2 has been found in Crohn's disease (CD), but little is known regarding its function in the pathophysiology of the disease.

Qiyun Tang

Qianqian Ji

Weiwei Xia

Liren Li

Jian'an Bai

Runzhou Ni

Yongwei Qin

Digestive diseases and sciences

Dig Dis Sci

Pyruvate kinase M2 regulates apoptosis of intestinal epithelial cells in Crohn's disease.

Intestinal fibrosis is a major complication of CD and may result in stricture formation leading to intestinal obstruction. MSCs play multiple roles in active CD and fibrosis-associated diseases.

Lei Lian

Qunsheng Huang

Longjuan Zhang

Huabo Qin

Xiaosheng He

Xin He

Jia Ke

Minghao Xie

Ping Lan

Anti-fibrogenic Potential of Mesenchymal Stromal Cells in Treating Fibrosis in Crohn's Disease.

间充质基质细胞在治疗克罗恩病纤维化中的抗纤维化潜能。

Barrier function is essential for the maintenance of normal intestinal function. Dysregulation of the intestinal barrier underlies a wide range of disorders.

Hong-Bo Wang

Peng-Yuan Wang

Xin Wang

Yuan-Lian Wan

Yu-Cun Liu

Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein Claudin-1 transcription.

丁酸通过上调紧密连接蛋白Claudin-1的转录增强肠道上皮屏障功能。

Statins reduce cardiovascular risk. Patients with cirrhosis have decreased hepatic clearance of statins and potentially increased risk for complications. No studies assess mortality in patients with biopsy-confirmed cirrhosis.

Sonal Kumar

Norman D Grace

Amir A Qamar

Statin use in patients with cirrhosis: a retrospective cohort study.

他汀类药物在肝硬化患者中的使用：一项回顾性队列研究。

Anemia is the most common extraintestinal systemic complication of inflammatory bowel disease. Iron deficiency anemia and anemia of chronic disease are among the most frequent types. Intestinal iron absorption is controlled by the activity of ferroportin. Cells with high expression of ferroportin include enterocytes, and also macrophages and hepatocytes. Iron homeostasis is controlled by the hepcidin-ferroportin axis. Hepcidin is a central regulator of iron metabolism and can also serve as a marker of systemic inflammation. During systemic inflammatory response, the synthesis of hepcidin increases, and hepcidin binds to ferroportin and inhibits its activity. Thus, iron is not absorbed from the bowel into the circulation and also remains sequestered in macrophages. Conversely, hepcidin synthesis is suppressed during conditions requiring increased iron intake for enhanced erythropoiesis, such as iron deficiency anemia or hypoxia. Here, ferroportin is not blocked, and iron is actively absorbed into the bloodstream and also released from the stores. Production of hepcidin is influenced by the status of total body iron stores, systemic inflammatory activity and erythropoietic activity. Oral iron therapy is limited in inflammatory bowel diseases due to ongoing gastrointestinal inflammation. It is less effective and may worsen the underlying disease. Therefore, the choice between oral and parenteral iron therapy must be made with caution. Oral iron would be ineffective at high hepcidin levels due to concurrent ferroportin blockage. Contrarily, low levels of hepcidin indicate that oral iron therapy should be successful. An understanding of hepcidin can help in understanding the body's reaction to iron depletion during the inflammatory process.

Eva Karaskova

Dagmar Pospisilova

Maria Velganova-Veghova

Milos Geryk

Jana Volejnikova

Dusan Holub

Marian Hajduch

Importance of Hepcidin in the Etiopathogenesis of Anemia in Inflammatory Bowel Disease.

炎症性肠病贫血发病机制中肝素的重要性。

Gastroesophageal reflux disease (GERD) is a very common condition characterized by chronic symptoms, such as heartburn or epigastric and/or substernal pain, that are frequently associated with mucosal damage resulting from abnormal reflux of gastric contents into the esophagus (Fass et al. in Nat Rev Dis Primers 7:55, 2021; Richter and Rubenstein in Gastroenterology 154:267-276, 2018). However, this damage can manifest in patients who do not exhibit typical GERD symptoms. Asymptomatic erosive esophagitis (AEE) is a condition in which there is esophageal mucosal injury typical for GERD, such as erosions, ulcerations, and/or Barrett's esophagus, visible in upper endoscopy, without concurrent symptoms attributable to GERD. AEE has been challenging to study, and it is not yet clear what causes this condition. As a result, there are no definitive guidelines on how to manage it. AEE also has the potential to be very impactful on public health, as those who are affected may go years without a diagnosis, putting them at risk for a variety of complications, including strictures and even cancer. Further careful study is necessary in order to more effectively address this condition. Here, we provide a comprehensive review of the scientific literature regarding AEE, examining its prevalence, clinical characteristics, potential causes and contributing factors, as well as identifying avenues for better characterization and management of this patient population.

Yixuan Du

Ashley Spencer

Pabitra Roy

Ahmed Abdulhamid

Shannon Dalessio

John Levenick

Jennifer Maranki

Hadie Razjouyan

Matthew D. Coates

Digestive Diseases and Sciences

Asymptomatic Erosive Esophagitis

无症状性糜烂性食管炎

The feasibility and outcomes of salvage endoscopic submucosal dissection (ESD) and ESD for metachronous esophageal squamous cell cancer (ESCC) inside the irradiated field are not clear.

Yasuhiro Inokuchi

Kyoko Furusawa

Kei Hayashi

Shin Maeda

Endoscopic Submucosal Dissection for Recurrent Esophageal Squamous Cell Carcinoma Post-Radiation

放射治疗后复发性食管鳞状细胞癌的内镜黏膜下剥离术

Bianca N. Islam

Fabio Cominelli

Concise Commentary: Out for Blood—Persisting Racial Disparities of Postoperative Complications in Minority Patients with IBD

简明评论：为血而战——IBD少数族裔患者术后并发症的持续种族差异

Endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (LNPCPs) offers excellent efficacy and safety. Referral biopsies are commonly obtained prior to EMR despite their potential adverse effects. We aimed to assess the diagnostic accuracy of referral biopsy as compared with optical evaluations and the polyp's final pathology.

Yuri Gorelik

Alexander Korytny

Tarek Arraf

Nour Arsheid

Fares Mazzawi

Rawia Moalem

Halim Awadie

Amir Klein

Diagnostic Accuracy of Referral Biopsy Compared to Optical Biopsy in Large Non-pedunculated Colorectal Polyps

转诊活检与光学活检在大非带蒂结直肠息肉中的诊断准确性比较

Recent U.S. registry publications showed no improvement in long-term survival post-liver transplant in the last three decades. Cardiovascular disease was a leading cause of post-transplant mortality. This observation urged us to assess the trend in long-term survival of Canadian liver transplant recipients (LTR) in comparison to other countries, and examine trends in cause-specific mortality.

Xun Zhao

Chaoqun Xu

Chinmay Bera

Fakhar Ali Qazi Arisar

Maryam Naghibzadeh

Amirhossein Azhie

Shiyi Chen

Wei Xu

Nazia Selzner

Cynthia Tsien

Leslie Lilly

Elmar Jaeckel

Mamatha Bhat

Long-Term Survival of Canadian Liver Transplant Recipients Remains Stagnant— A Cohort Study on the Evolution of Cause-Specific Mortality

加拿大肝移植受者长期生存率仍停滞不前——一项关于特定死因死亡率演变的前瞻性研究

Abbreviation	Dig Dis Sci
Journal Impact	2.44
Quartiles(Global)	GASTROENTEROLOGY & HEPATOLOGY(Q2)

ISSN	0002-9211, 0163-2116, 1573-2568
h-index	140

Publication Information	Publisher: Plenum Publishers，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1934，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

American Journal of Digestive Diseases

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