与日常实践直接相关的多学科信息ANNALES DE BIOLOGIE CLINIQUE 是法国临床生物学学会 (SFBC) 的官方期刊，在继续教育、实验室认证和技术验证等领域为生物学家提供支持。提供日常实践的原创文章、摘要和账户，该杂志提供知识、技术和设备进步的详细信息，以及对整个社区开放的讨论论坛。

The "Annales de Biologie Clinique" is the official journal of the French Society of Clinical Biology (SFBC), providing multidisciplinary information closely related to daily practice. This journal supports biologists in areas such as continuing education, laboratory accreditation, and technical validation. It publishes original articles, abstracts, and case reports, offering detailed insights into advancements in knowledge, technology, and equipment, along with an open discussion forum for the entire community.

《Annales de Biologie Clinique》是法国临床生物学学会（SFBC）的官方期刊，提供与日常实践密切相关的多学科信息。该期刊为生物学家在继续教育、实验室认证和技术验证等领域提供支持。它发表原创文章、摘要和案例，详细介绍知识、技术和设备的进步，并设有一个开放的讨论论坛，供整个社区交流。

Annales de Biologie Clinique

Dyslipidemia plays an essential role in the occurrence and development of cardiovascular diseases, and the regulation of cholesterol and triglyceride metabolism has been applied in the diagnosis, treatment and prognosis of clinical cardiovascular diseases. Following advances in methodology in recent years, low-density lipoprotein triglycerides (LDL-TG) has been identified as a potential risk factor for the development of cardiovascular disease and has some clinical significance in its diagnosis and treatment. Meanwhile, LDL-TG metabolism regulation may also be involved in the development of type 2 diabetes, chronic kidney disease, hypothyroidism and other diseases, which may improve our understanding of the prevention, control and risk assessment of clinically relevant diseases.

Xiangniang Li

Hao Shen

Annales de biologie clinique

Low-density lipoprotein triglycerides: A marker for metabolic diseases

低密度脂蛋白甘油三酯：代谢性疾病的标志物

It is important that a clinical laboratory has implemented appropriate procedures for quality control, which includes both internal quality control (IQC) and external quality assessment (EQA) with the common goal to detect systematic errors and random errors. It is the case for both the Hemohub® Bayesian tools for IQC results interpretation and the ECAT EQA optimised bivariate z-scores analysis. On a concrete case study, we demonstrate both the higher sensitivity and specificity of optimised bivariate z-scores analysis than the univariate approach. The Bayesian IQC results interpretation like the ECAT analysis confirmed the explicit conclusion i.e. an increase of the random error corresponding to the increase of the inter assay coefficient of variation (CV) at the date of EQA samples runs. Improvement of repaired dysfunction could be then daily observed on IQC results and then confirmed on EQA results thanks to the complementarity of the two approaches.

Emilie Jousselme

Piet Meijer

Frédéric Sobas

Panagiotis Tsiamyrtzis

Complementarity between Bayesian Internal Quality Control results management and External Quality Assessment bivariate z-score analysis: application to a concrete case study

贝叶斯内部质量控制结果管理与外部质量评估双变量z分数分析的互补性：应用于具体案例研究

Detection of schistocytes is an important first step in the differential diagnosis of thrombotic microangiopathy. It is however labor intensive and prone to subjectivity. To improve and standardize the detection and quantification of schistocytes, we studied its automated analysis by digital microscopy DM1200 (CellaVision®) on 63 positive and 102 negative smears obtained from SP-50 (Sysmex®). Easy to use and very useful for staff training, it showed a lower between-observer coefficient of variation than usually described for manual counting (25% vs. 50%). Very sensitive (100%) in pre-classification, the detection of schistocytes was highly sensitive (98.4%) and specific (96.8%) after reclassification (AUCROC = 0.9929), showing a good correlation with manual microscopy. TAT was comparable to manual counting. For positive smears, the percentage of schistocytes was similar between pre- and post-classification. However, 29.6% of pre-classified schistocytes were removed and 21.8% were added. For negative smears a significative overestimation of schistocytes (292%) was observed. Except poikilocytosis, on negative smears, the most common error of the software (24.9%) was due to platelets classified in schistocytes. Were also observed for example erroneous divisions of the image (3.2%) or artifactual schistocytes resulting from scratches in the smear (2.6%). Another limit is the high number of red blood cells not analyzed (46.8% for high-density smears), which might false the schistocytes percentage. To conclude, CellaVision® technology showed many benefits, but also limits that the operator needs to know.

Sami Zouitina

Frédérique Dubois-Galopin

Evaluation of the CellaVision® DM-1200 system for detecting and quantifying schistocytes

CellaVision® DM-1200系统在检测和定量裂红细胞中的评估

Tuberculosis remains one of the leading causes of mortality worldwide. Microscopy and culture still the references of Tuberculosis diagnosis. Microscopy has a low sensitivity, specificity and culture is time consuming. For this reason, rapid and reliable diagnosis of the disease is required. We describe a retrospective comparison study of tuberculosis diagnosis by PCR IS6110 directly from blood samples of patients with suspected Tuberculosis with Acid-Fast-Bacilli and culture. From 80 patients enrolled, culture results were positive for 25, acid fast bacilli were positive for 15 and blood PCR were positive for 45. Comparing blood PCR result with acid fast bacilli, the sensitivity and specificity were respectively 35% and 87.5% (PPV = 9%, PNV = 21.1%) for PTB. The specificity of blood PCR was 100% (PNV = 72.73%), for EPTB. In comparison with culture blood PCR have a high sensitivity and specificity better than with the acid fast, they were respectively 57.89%, 100% for PTB and 50%, 100% for EPTB. This study is the first established in Tunisia and in Africa aiming to diagnose TB from blood. B-PCR results has shown a high correlation with culture that illustrates the usefulness of B-PCR as a rapid and early diagnostic, combined with others serological results B-PCR can be a solid, rapid and efficient TB diagnostic tools.

Ahmed Ben Hadj Hassine

Manel Marzouk

Jalel Boukadida

Rapid diagnosis of tuberculosis by PCR IS6110 from blood in the central region of Tunisia

突尼斯中部地区通过PCR IS6110从血液中快速诊断结核病

A new direction of research was established due to biofilms' infections caused by a mixture of fungal and bacterial species. Diagnosis of these infections becomes more difficult and high doses of drugs are used in treatment, especially in critically ill patients. The aim of the current study was to examine the effects of amphotericin B, in combination with imipenem or colistin against Candida albicans - Acinetobacter baumannii- Proteus mirabilis and Candida tropicalis - Acinetobacter baumannii -Proteus mirabilis polymicrobial biofilms. According to the microdilution method of the Clinical Laboratory Standards Institute (CLSI) published in documents M27-A3 (2008) and M07-A10 (2015) respectively, the susceptibility of the clinical isolates Candida yeasts to amphotericin B and Gram-negative bacteria to imipenem and colistin was determined. A Checkerboard assay was employed to evaluate the efficacy of drugs combinations. The 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide (MTT) reduction assay was used to quantify the biofilms. The combination amphotericin B/colistin and amphotericin B/imipenem did not produce obvious effects against the polymicrobial biofilms formed for 48 hours. Whereas colistin alone produced strong effects against Candida albicans-Acinetobacter baumannii and Candida albicans - Acinetobacter baumannii -Proteus mirabilis compared to Candida tropicalis - Acinetobacter baumannii and Candida tropicalis - Acinetobacter baumannii - Proteus mirabilis polymicrobial biofilms. For mixed Candida spp. bacterial biofilms, these results point to the difficulties in eradicating these biofilms, as well as in preventing their development.

Abbreviation	Ann. Biol. Clin. (Paris).
Journal Impact	0.37
Quartiles(Global)	MEDICINE, RESEARCH & EXPERIMENTAL(Q4)

ISSN	0003-3898, 1950-6112
h-index	31

Publication Information	Publisher: John Libbey，Publishing cycle: Bimonthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1945，Proportion of original research papers: 92.31%，Self Citation Rate:25.00%， Gold OA Rate: 0.57%
Average review cycle	网友分享经验：较慢,6-12周
Average recruitment ratio	网友分享经验：容易

Annales de Biologie Clinique

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Low-density lipoprotein triglycerides: A marker for metabolic diseases

Complementarity between Bayesian Internal Quality Control results management and External Quality Assessment bivariate z-score analysis: application to a concrete case study

Evaluation of the CellaVision® DM-1200 system for detecting and quantifying schistocytes

Rapid diagnosis of tuberculosis by PCR IS6110 from blood in the central region of Tunisia

In vitro activity of amphotericin B in combination with imipenem/colistin against mixed cultures of Candida spp. and Gram-negative bacteria

Complementarity between Bayesian Internal Quality Control results management and External Quality Assessment bivariate z-score analysis: application to a concrete case study

Evaluation of the CellaVision® DM-1200 system for detecting and quantifying schistocytes

Rapid diagnosis of tuberculosis by PCR IS6110 from blood in the central region of Tunisia

In vitro activity of amphotericin B in combination with imipenem/colistin against mixed cultures of Candida spp. and Gram-negative bacteria

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