Arquivos Brasileiros de Endocrinologia e Metabologia

Background: The ADRA2A gene codes for the adrenoceptor alpha 2A, that participate from insulin secretion regulation. Therefore, this gene is a functional candidate for carrying susceptibility alleles for type diabetes mellitus. The polymorphism rs10885122 in ADRA2A gene was associated with lower fasting glucose levels and reduced glucose-stimulated insulin release. Objective: To investigated the association of the polymorphism rs10885122G>T in ADRA2A gene in a Euro-Brazilian sample of healthy (controls) or type 2 diabetic (T2D). Subjects and Methods: We genotype with fluorescent probes (TaqMan) 241 subjects, 121 healthy subjects and 120 T2D classified according Brazilian Diabetes Association (2013) and American Diabetes Association (2014) criteria. Results: The genotype and allele frequencies showed no significative (P>0.05) difference between the two studied groups. The minor allele (T) frequencies (95%CI) for rs10885122 were 19% (14-24%) and 20% (15-26%), respectively, for healthy and T2D groups. Carriers of T allele (genotypes GT+TT) were associated to a significative (P=0.016) body weight reduction in about 7 kg when compared to the genotype GG only in T2G group. Conclusion: The polymorphism rs10885122G>T of ADRA2A gene was not associated with T2D in Euro-Brazilians and carriers of T allele showed a lower body weight in the presence of T2D.

Marciane Welter

Henrique Ravanhol Frigeri

Rosângela Roginski Réa

Emanuel Maltempi de Souza

Dayane Alberton

Geraldo Picheth

Fabiane Gomes de Moraes Rego

Arquivos Brasileiros de Endocrinologia & Metabologia

Polymorphism rs10885122 of the adrenoceptor alpha 2A (ADRA2A) gene in Euro-Brazilians with type 2 Diabetes mellitus

肾上腺素受体α2A（ADRA2A）基因多态性rs10885122在患有2型糖尿病的欧裔巴西人中的研究

A cross-sectional study in which we evaluated 665 girls, part of a sample of 1095 schoolchildren of both sexes representing the schoolchildren population in Uberaba. The objective of this study was to find out the age at which puberty begins, the age of menarche and anthropometrics of the participants at different stages of puberty. We found that thelarche was attained at the age of 9.8 ± 1.4 years and menarche at 11.7 ± 1.3. The prevalence of excess weight was 32%; 95% of the participants began thelarche between the age of 7 and 12 years. These values indicate a secular tendency to the reduction of the age of menarche and earlier beginning of puberty. It is very important to know these parameters in order to establish public policies aiming at plans to prevent these early events, especially regarding control of the prevalence of obesity, one of the factors associated with these changes, and also attention to the consequences of sexual precociousness, ranging from the risk of early pregnancy to the higher probability of breast cancer and psychosocial disorders.

Taciana Carla Maia Feibelmann

Adriana Paula da Silva

Daniela Cristina Silva Silva

Elisabete Aparecida Mantovani Rodrigues Resende

Lúcia Marina Scatena

Maria de Fátima Borges

1-PUBERTY IN A SAMPLE OF BRAZILIAN SCHOOLGIRLS: TIMING, EVOLUTION AND ANTHROPOMETRIC CHARACTERISTICS.

巴西学龄女童青春期：时间、演变与人体测量特征。

Malignant insulinomas are frequently diagnosed at a late stage. Medical management is necessary to slow progression of the disease and control of hypoglycemic symptoms when cure by surgical treatment is not possible. Multimodal treatment, in these cases, has been used with variable clinical response. We describe a 68-yr-old woman who presented response failure to usual treatment and was alternatively treated with radiolabeled metaiodobenzylguanidine ([131I]-MIBG) analogue therapy with development of neurologic complications. We also present a review of the current role of [131I]-MIBG treatment in insulinomas.

Alina Coutinho Rodrigues Feitosa

Dálvaro Castro-Júnior

José Rocha-Filho

Melba Moura

Marcony Queiroz Andrade

Adelina Sanches

Spinal cord compression after radiolabeled metaiodobenzylguanidine analogue therapy in advanced malignant insulinoma.

晚期恶性胰岛素瘤患者接受放射性碘化间碘苯甲胍类似物治疗后的脊髓压迫。

Objetivo: Avaliar se existe associacao entre o perfil lipidico materno alterado e o perfil lipidico do recem-nascido em uma maternidade. Metodo: Estudo transversal realizado com 435 parturientes e seus receptivos recem-nascidos. As amostras de sangue dos recem-nascidos foram colhidas no momento do parto, por meio de puncao da veia do cordao umbilical proximo a placenta. As amostras de sangue das parturientes foram colhidas na sala de pre-parto ou logo apos o parto. As concentracoes de colesterol total, triglicerideos, HDL-c foram determinadas pelo metodo enzimatico colorimetrico e os valores de LDL-c determinado pela formula de Friedewald. Resultados: A concentracao media de colesterol total dos recem–nascidos de maes com LDL-c alterado foi significativamente (p<0,05) maior do que os recem-nascidos de maes com LDL-c nao alterado (30,7 mg/dL vs. 29,7 mg/dL). Para as demais variaveis analisadas, nao houve diferenca significativa das concentracoes de LDL-c (29,9 mg/dL), HDL-c ( 21,7 mg/dL) e triglicerideos (30,3 mg/dL) dos recem-nascidos em relacao as concentracoes de colesterol total (208,1 mg/dL), LDL-c (112,7 mg/dL), HDL-c (56,3 mg/dL) e triglicerideos (197,8 mg/dL) das maes. Conclusoes: Recem-nascidos que apresentaram significativamente maior media de colesterol total no plasma foram os de maes com LDL-c alterado.

Willian Barbosa Sales

Silleno Dias Junior

Caroline Kroll

Silmara Mastroeni

Jean Carl Silva

Marco Fabio Mastroeni

INFLUÊNCIA DO PERFIL LIPÍDICO MATERNO ALTERADO NO PERFIL LIPÍDICO DO RECÉM–NASCIDO

母体血脂异常对新生儿血脂谱的影响

Objective: To compare the occurrence of hypoglycemia during hemodialysis in chronic kidney disease diabetic patients who present different levels of pre-dialysis glycemia both when using dialysis solutions with and without glucose.
Subjects and Methods: Twenty diabetic patients in maintenance hemodialysis were submitted to three dialysis sessions (at a 7-day interval each) with dialysis solutions without glucose, with glucose at 55mg/dL, and at 90mg/dL subsequently. Blood glucose levels were measured immediately pre-dialysis and at 4 moments during the session, and values under 70mg/dL were considered as hypoglycemia. 
Results: Average pre-dialysis glycemia was lower in those who presented intra-dialytic hypoglycemia than in those who did not, both in glucose-free (140.4±50.7 vs. 277.7±91.0mg/dL; p=0.005; 95%CI:46.4 to 228.1) and in glucose 55mg/dL (89.5±10.6 vs. 229.7±105.0mg/dL; p<0.05; 95%CI:9.8 to 270.5). In patients with pre-dialysis glycemia under 140mg/dL, average intradialytic glycemia was significantly lower than pre-dialysis glycemia only when using glucose-free dialysate (p<0.0001; 95%CI:29.9 to 56.0 - t-test). Hypoglycemia during dialysis was observed only when using glucose-free or glucose-poor dialysis solutions. 
Conclusions: The use of glucose-free or glucose-poor dialysis solution presents a high risk of intradialytic hypoglycemia in diabetic renal patients, especially in those with presumed better glycemic control.

Jayme Eduardo Burmeister

Diego da Rosa Miltersteiner

Bruna Ortega Burmeister

Juliana Fernandes Campos

Risk of hypoglycemia during hemodiaysis in diabetic patients is related to lower pre-dialysis glycemia

糖尿病患者血液透析期间低血糖风险与透析前血糖水平较低相关

Objetivo:  Avaliar as alteracoes osseas presentes na prole de ratas induzidas ao hipertireoidismo durante a gestacao e lactacao, e verificar a reversibilidade dessas alteracoes apos o desmame. Material e metodos: Utilizaram-se 20 ratas Wistar, distribuidas nos grupos hipertireoideo e controle, tratados diariamente com L-tiroxina (50μg/animal) e placebo, respectivamente. O tratamento iniciou-se sete dias antes da copula e se estendeu por toda a gestacao e lactacao. De cada mae dos dois grupos, foram eutanasiados dois filhotes ao nascimento, dois filhotes com 21 dias (dia do desmame) e dois filhotes com 42 dias de idade (21 dias pos desmame). Nos neonatos, mensurou-se o comprimento do membro pelvico e toracico e nos demais animais, foi medido o comprimento e a largura do femur e do umero. Os ossos foram dissecados, descalcificados e processados pela tecnica de inclusao em parafina, para analises histomorfometricas. Resultados: O hipertireoidismo materno reduziu significativamente o comprimento do membro pelvico dos neonatos. Nos filhotes com 21 dias de idade, o hipertireoidismo reduziu o comprimento e a largura do femur e do umero e aumentou a espessura da placa epifisaria e a porcentagem de tecido osseo trabecular. No entanto, 21 dias apos o desmame nao houve diferencas significativas entre grupos no que se refere aos parâmetros avaliados nos periodos anteriores. Conclusao: O hipertireoidismo materno reduz o crescimento da prole de ratas ao nascimento e ao desmame, aumenta a porcentagem de tecido osseo trabecular dos lactentes e que essas alteracoes sao reversiveis 21 dias apos o desmame.

Rogéria Serakides

Mariana Zanini Maia

Gianne Karla Santos

Ana Claudia Moura Batista

Amanda Maria Sena Reis

Juneo Freitas Silva

Lorena Gabriele Rocha Ribeiro

Natalia Melo Ocarino

Efeito do hipertireoidismo materno nos ossos da prole de ratas do nascimento ao pós-desmame

母体甲状腺功能亢进对大鼠后代骨骼从出生到断奶期间的影响

O numero de pacientes com diagnostico de diabetes aumenta progressivamente. O processo arteriosclerotico nos diabeticos desenvolve-se precocemente e de forma mais difusa e acelerada que na populacao geral. Infarto agudo do miocardio (IAM) e acidente vascular cerebral constituem as principais causas de obito neste grupo. Muitas vezes IAM desenvolve-se de forma assintomatica ou com sintomas inespecificos e invariavelmente e a forma inicial de apresentacao da doenca arterial coronaria necessitando, portanto de rastreamento para diagnostico precoce. O objetivo deste artigo de revisao consiste em discutir os principais aspectos da populacao diabetica afetada pela Doenca arterial coronaria e os metodos diagnosticos disponiveis para rastreamento de doenca arterial coronaria em pacientes diabeticos assintomaticos.

Carlos Augusto Fernandes Tavares

Bernardo Leo Wajchenberg

Carlos Eduardo Rochitte

Antonio Carlos Lerario

Rastreamento da Doença Arterial Coronária Assintomática em Pacientes com Diabetes Mellitus tipo 2

2型糖尿病患者无症状冠状动脉疾病的追踪

Background: Symptoms and signs of the hypothyroidism vary in relation to the magnitude and acuteness of the thyroid hormone deficiency. The usual clinical features are constipation, fatigue, cold intolerance and weight gain. Rarely it can present with neurologic problems like reversible cerebellar ataxia, dementia, peripheral neuropathy, psychosis and coma. Hypothyroidism should be suspected in all cases of ataxia, as it is easily treatable. Patient findings: A 40 year-old male presented with the history facial puffiness, hoarseness of voice and gait-ataxia. Investigations revealed frank primary hypothyroidism. Anti-TPO antibody was positive. Thyroxine was started and patient improved completely within eight weeks. Conclusions: Hypothyroidism can present with ataxia as predominant feature. Hypothyroidism should be considered in all cases of cerebellar ataxia as it is a reversible cause of ataxia.

涉及主题	医学生物内科学内分泌学化学病理遗传学生物化学糖尿病
出版信息	出版商: Sociedade Brasileira de Endocrinologia e Metabologia，出版周期: Monthly，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2004，原创研究文献占比: 0.00%，自引率:N.A.， Gold OA占比: 0.00%
平均审稿周期	网友分享经验：偏慢,4-8周
平均录用比例	网友分享经验：容易

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Polymorphism rs10885122 of the adrenoceptor alpha 2A (ADRA2A) gene in Euro-Brazilians with type 2 Diabetes mellitus

1-PUBERTY IN A SAMPLE OF BRAZILIAN SCHOOLGIRLS: TIMING, EVOLUTION AND ANTHROPOMETRIC CHARACTERISTICS.

Spinal cord compression after radiolabeled metaiodobenzylguanidine analogue therapy in advanced malignant insulinoma.

INFLUÊNCIA DO PERFIL LIPÍDICO MATERNO ALTERADO NO PERFIL LIPÍDICO DO RECÉM–NASCIDO

Risk of hypoglycemia during hemodiaysis in diabetic patients is related to lower pre-dialysis glycemia

Efeito do hipertireoidismo materno nos ossos da prole de ratas do nascimento ao pós-desmame

Rastreamento da Doença Arterial Coronária Assintomática em Pacientes com Diabetes Mellitus tipo 2

Cerebellar Ataxia as Presenting Feature of Hypothyroidism. A Case Report.

Efeito do hipertireoidismo materno nos ossos da prole de ratas do nascimento ao pós-desmame

Rastreamento da Doença Arterial Coronária Assintomática em Pacientes com Diabetes Mellitus tipo 2