化学评论是涵盖化学一般主题的最受推崇和排名最高的期刊之一。化学评论的使命是对有机、无机、物理、分析方面的重要近期研究提供全面、权威、批判性和可读性的评论、理论和生物化学。除了一般评论外，该杂志自 1985 年以来还出版了定期主题问题，侧重于新兴研究的单一主题或方向。

Chemical Reviews is one of the most esteemed and highly ranked journals covering general topics in chemistry. The mission of Chemical Reviews is to provide comprehensive, authoritative, critical, and readable reviews, theories, and biochemical analyses of significant recent research in organic, inorganic, physical, and analytical chemistry. In addition to general reviews, the journal has published regular thematic issues since 1985, focusing on a single emerging research topic or direction.

《Chemical Reviews》是涵盖化学各个领域的最受推崇和排名最高的期刊之一。该期刊的使命是提供对有机、无机、物理和分析化学领域重要近期研究的全面、权威、批判性和可读性的评论、理论和生物化学分析。自1985年以来，除了常规评论外，《Chemical Reviews》还定期出版主题专刊，聚焦于新兴研究的特定主题或方向。

Chemical Reviews

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA survey of Hammett substituent constants and resonance and field parametersCorwin. Hansch, A. Leo, and R. W. TaftCite this: Chem. Rev. 1991, 91, 2, 165–195Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/cr00002a004https://doi.org/10.1021/cr00002a004research-articleACS PublicationsRequest reuse permissionsArticle Views63411Altmetric-Citations7091LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Corwin. Hansch

A. Leo

R. W. Taft

Chem. Rev.

A survey of Hammett substituent constants and resonance and field parameters

This review examines the detailed chemical insights that have been generated through 150 years of work worldwide on magnesium-based inorganic cements, with a focus on both scientific and patent literature. Magnesium carbonate, phosphate, silicate-hydrate, and oxysalt (both chloride and sulfate) cements are all assessed. Many such cements are ideally suited to specialist applications in precast construction, road repair, and other fields including nuclear waste immobilization. The majority of MgO-based cements are more costly to produce than Portland cement because of the relatively high cost of reactive sources of MgO and do not have a sufficiently high internal pH to passivate mild steel reinforcing bars. This precludes MgO-based cements from providing a large-scale replacement for Portland cement in the production of steel-reinforced concretes for civil engineering applications, despite the potential for CO2 emissions reductions offered by some such systems. Nonetheless, in uses that do not require steel reinforcement, and in locations where the MgO can be sourced at a competitive price, a detailed understanding of these systems enables their specification, design, and selection as advanced engineering materials with a strongly defined chemical basis.

Sam A. Walling

John L. Provis

Magnesia-Based Cements: A Journey of 150 Years, and Cements for the Future?

The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer, but new platinum agents have been very slow to enter the clinic. Recently, however, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs. The use of nanodelivery devices has also grown, and many different strategies have been explored to incorporate platinum warheads into nanomedicine constructs. In this Review, we discuss these efforts to create the next generation of platinum anticancer drugs. The introduction provides the reader with a brief overview of the use, development, and mechanism of action of the approved platinum drugs to provide the context in which more recent research has flourished. We then describe approaches that explore nonclassical platinum(II) complexes with trans geometry or with a monofunctional coordination mode, polynuclear platinum(II) compounds, platinum(IV) prodrugs, dual-threat agents, and photoactivatable platinum(IV) complexes. Nanoparticles designed to deliver platinum(IV) complexes will also be discussed, including carbon nanotubes, carbon nanoparticles, gold nanoparticles, quantum dots, upconversion nanoparticles, and polymeric micelles. Additional nanoformulations, including supramolecular self-assembled structures, proteins, peptides, metal-organic frameworks, and coordination polymers, will then be described. Finally, the significant clinical progress made by nanoparticle formulations of platinum(II) agents will be reviewed. We anticipate that such a synthesis of disparate research efforts will not only help to generate new drug development ideas and strategies, but also will reflect our optimism that the next generation of approved platinum cancer drugs is about to arrive.

Timothy C. Johnstone

Kogularamanan Suntharalingam

Stephen J. Lippard

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Flavylium compounds are a well-known family of pigments because they are prevalent in the plant kingdom, contributing to colors over a wide range from shades of yellow-red to blue in fruits, flowers, leaves, and other plant parts. Flavylium compounds include a large variety of natural compound classes, namely, anthocyanins, 3-deoxyanthocyanidins, auronidins, and their respective aglycones as well as anthocyanin-derived pigments (e.g., pyranoanthocyanins, anthocyanin-flavan-3-ol dimers). During the past few decades, there has been increasing interest among chemists in synthesizing different flavylium compounds that mimic natural structures but with different substitution patterns that present a variety of spectroscopic characteristics in view of their applications in different industrial fields. This Review provides an overview of the chemistry of flavylium-based compounds, in particular, the synthetic and enzymatic approaches and mechanisms reported in the literature for obtaining different classes of pigments, their physical-chemical properties in relation to their pH-dependent equilibria network, and their chemical and enzymatic degradation. The development of flavylium-based systems is also described throughout this Review for emergent applications to explore some of the physical-chemical properties of the multistate of species generated by these compounds.

Luis Cruz

Nuno Basílio

Nuno Mateus

Victor de Freitas

Fernando Pina

Natural and Synthetic Flavylium-Based Dyes: The Chemistry Behind the Color

Since the initial landmark study on the chiral induced spin selectivity (CISS) effect in 1999, considerable experimental and theoretical efforts have been made to understand the physical underpinnings and mechanistic features of this interesting phenomenon. As first formulated, the CISS effect refers to the innate ability of chiral materials to act as spin filters for electron transport; however, more recent experiments demonstrate that displacement currents arising from charge polarization of chiral molecules lead to spin polarization without the need for net charge flow. With its identification of a fundamental connection between chiral symmetry and electron spin in molecules and materials, CISS promises profound and ubiquitous implications for existing technologies and new approaches to answering age old questions, such as the homochiral nature of life. This review begins with a discussion of the different methods for measuring CISS and then provides a comprehensive overview of molecules and materials known to exhibit CISS-based phenomena before proceeding to identify structure-property relations and to delineate the leading theoretical models for the CISS effect. Next, it identifies some implications of CISS in physics, chemistry, and biology. The discussion ends with a critical assessment of the CISS field and some comments on its future outlook.

Brian P. Bloom

Yossi Paltiel

Ron Naaman

David H. Waldeck

Chiral Induced Spin Selectivity

Conventional artificial intelligence (AI) systems are facing bottlenecks due to the fundamental mismatches between AI models, which rely on parallel, in-memory, and dynamic computation, and traditional transistors, which have been designed and optimized for sequential logic operations. This calls for the development of novel computing units beyond transistors. Inspired by the high efficiency and adaptability of biological neural networks, computing systems mimicking the capabilities of biological structures are gaining more attention. Ion-based memristive devices (IMDs), owing to the intrinsic functional similarities to their biological counterparts, hold significant promise for implementing emerging neuromorphic learning and computing algorithms. In this article, we review the fundamental mechanisms of IMDs based on ion drift and diffusion to elucidate the origins of their diverse dynamics. We then examine how these mechanisms operate within different materials to enable IMDs with various types of switching behaviors, leading to a wide range of applications, from emulating biological components to realizing specialized computing requirements. Furthermore, we explore the potential for IMDs to be modified and tuned to achieve customized dynamics, which positions them as one of the most promising hardware candidates for executing bioinspired algorithms with unique specifications. Finally, we identify the challenges currently facing IMDs that hinder their widespread usage and highlight emerging research directions that could significantly benefit from incorporating IMDs.

Ruoyu Zhao

Seung Ju Kim

Yichun Xu

Jian Zhao

Tong Wang

Rivu Midya

Sabyasachi Ganguli

Ajit K. Roy

Madan Dubey

R. Stanley Williams

J. Joshua Yang

Memristive Ion Dynamics to Enable Biorealistic Computing

忆阻离子动力学实现生物逼真计算

Core–shell magnetic particles consisting of magnetic core and functional shells have aroused widespread attention in multidisciplinary fields spanning chemistry, materials science, physics, biomedicine, and bioengineering due to their distinctive magnetic properties, tunable interface features, and elaborately designed compositions. In recent decades, various surface engineering strategies have been developed to endow them desired properties (e.g., surface hydrophilicity, roughness, acidity, target recognition) for efficient applications in catalysis, optical modulation, environmental remediation, biomedicine, etc. Moreover, precise control over the shell structure features like thickness, porosity, crystallinity and compositions including metal oxides, carbon, silica, polymers, and metal–organic frameworks (MOFs) has been developed as the major method to exploit new functional materials. In this review, we highlight the synthesis methods, regulating strategies, interface engineering, and applications of core–shell magnetic particles over the past half-century. The fundamental methodologies for controllable synthesis of core–shell magnetic materials with diverse organic, inorganic, or hybrid compositions, surface morphology, and interface property are thoroughly elucidated and summarized. In addition, the influences of the synthesis conditions on the physicochemical properties (e.g., dispersibility, stability, stimulus-responsiveness, and surface functionality) are also discussed to provide constructive insight and guidelines for designing core–shell magnetic particles in specific applications. The brand-new concept of "core–shell assembly chemistry" holds great application potential in bioimaging, diagnosis, micro/nanorobots, and smart catalysis. Finally, the remaining challenges, future research directions and new applications for the core–shell magnetic particles are predicted and proposed.

Yidong Zou

Zhenkun Sun

Qiyue Wang

Yanmin Ju

Nianrong Sun

Qin Yue

Yu Deng

Shanbiao Liu

Shengfei Yang

Zhiyi Wang

Fangyuan Li

Yanglong Hou

Chunhui Deng

Daishun Ling

Yonghui Deng

Core–Shell Magnetic Particles: Tailored Synthesis and Applications

核壳磁性颗粒：定制合成与应用

InfoMetrics Chemical ReviewsVol 124/Issue 24Article CiteCitationCitation and abstractCitation and referencesMore citation options ShareShare onFacebookX (Twitter)WeChatLinkedInRedditEmailJump toExpandCollapse HighlightDecember 25, 2024Small Data Machine Learning Approaches in Molecular and Materials ScienceClick to copy article linkArticle link copied!Siddarth K. AcharSiddarth K. AcharComputational Modeling & Simulation Program, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United StatesDepartment of Chemical & Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United StatesMore by Siddarth K. AcharJohn A. Keith*John A. KeithDepartment of Chemical & Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States*E-mail: [email protected]More by John A. Keithhttps://orcid.org/0000-0002-6583-6322Other Access OptionsChemical ReviewsCite this: Chem. Rev. 2024, 124, 24, 13571–13573Click to copy citationCitation copied!https://pubs.acs.org/doi/10.1021/acs.chemrev.4c00957https://doi.org/10.1021/acs.chemrev.4c00957Published December 25, 2024 Publication History Received 10 December 2024Published online 25 December 2024Published in issue 25 December 2024in-briefCopyright © Published 2024 by American Chemical SocietyRequest reuse permissionsACS PublicationsCopyright © Published 2024 by American Chemical Society Subjectswhat are subjectsArticle subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article.First-principles calculationsMaterialsMaterials scienceMolecular modelingQuality management Note: In lieu of an abstract, this is the article's first page. Read this article To access this article, please review the available access options below. Get instant access Purchase Access Read this article for 48 hours. Check out below using your ACS ID or as a guest. Purchase Access Restore my guest access Recommended Access through Your Institution You may have access to this article through your institution. Your institution does not have access to this content. Add or change your institution or let them know you'd like them to include access. Access Through Recommend Publication Institution Name Loading Institutional Login Options... Access Through Your Institution Add or Change Institution Explore subscriptions for institutions Recommended Log in to Access You may have access to this article with your ACS ID if you have previously purchased it or have ACS member benefits. Log in below. Login with ACS ID Purchase access Purchase this article for 48 hours $48.00 Add to cart Purchase this article for 48 hours Checkout Cited By Click to copy section linkSection link copied!This article has not yet been cited by other publications.Download PDF Get e-AlertsGet e-AlertsChemical ReviewsCite this: Chem. Rev. 2024, 124, 24, 13571–13573Click to copy citationCitation copied!https://doi.org/10.1021/acs.chemrev.4c00957Published December 25, 2024 Publication History Received 10 December 2024Published online 25 December 2024Published in issue 25 December 2024Copyright © Published 2024 by American Chemical SocietyRequest reuse permissionsArticle Views-Altmetric-Citations-Learn about these metrics closeArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.Recommended Articles

Siddarth K. Achar

John A. Keith

Small Data Machine Learning Approaches in Molecular and Materials Science

分子与材料科学中的小数据机器学习方法

Human carbonic anhydrases (hCAs) are widespread zinc enzymes that catalyze the hydration of CO2 to bicarbonate and a proton. Currently, 15 isoforms have been identified, of which only 12 are catalytically active. Given their involvement in numerous physiological and pathological processes, hCAs are recognized therapeutic targets for the development of inhibitors with biomedical applications. However, despite massive development efforts, very few of the presently available hCA inhibitors show selectivity for a specific isoform. X-ray crystallography is a very useful tool for the rational drug design of enzyme inhibitors. In 2012 we published in Chemical Reviews a highly cited review on hCA family (Alterio, V. et al. Chem Rev. 2012, 112, 4421−4468), analyzing about 300 crystallographic structures of hCA/inhibitor complexes and describing the different CA inhibition mechanisms existing up to that date. However, in the period 2012–2023, almost 700 new hCA/inhibitor complex structures have been deposited in the PDB and a large number of new inhibitor classes have been discovered. Based on these considerations, the aim of this Review is to give a comprehensive update of the structural aspects of hCA/inhibitor interactions covering the period 2012–2023 and to recapitulate how this information can be used for the rational design of more selective versions of such inhibitors.

Katia D’Ambrosio

Anna Di Fiore

Vincenzo Alterio

Emma Langella

Simona Maria Monti

Claudiu T. Supuran

Giuseppina De Simone

Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity

抑制剂与人类碳酸酐酶的多重结合模式：关于活性同工型特异性调节剂设计的最新进展

Cell-free gene expression (CFE) systems empower synthetic biologists to build biological molecules and processes outside of living intact cells. The foundational principle is that precise, complex biomolecular transformations can be conducted in purified enzyme or crude cell lysate systems. This concept circumvents mechanisms that have evolved to facilitate species survival, bypasses limitations on molecular transport across the cell wall, and provides a significant departure from traditional, cell-based processes that rely on microscopic cellular "reactors." In addition, cell-free systems are inherently distributable through freeze-drying, which allows simple distribution before rehydration at the point-of-use. Furthermore, as cell-free systems are nonliving, they provide built-in safeguards for biocontainment without the constraints attendant on genetically modified organisms. These features have led to a significant increase in the development and use of CFE systems over the past two decades. Here, we discuss recent advances in CFE systems and highlight how they are transforming efforts to build cells, control genetic networks, and manufacture biobased products.

短名	Chem. Rev.
Journal Impact	51.58
国际分区	CHEMISTRY, MULTIDISCIPLINARY(Q1)
期刊索引	SCI Q1中科院 1 区

ISSN	0009-2665, 1520-6890
h-index	833
国内分区	化学(1区)化学化学综合(1区)
Top 期刊	是

涉及主题	化学有机化学材料科学生物物理生物化学工程类量子力学纳米技术复合材料
出版信息	出版商: American Chemical Society，出版周期: Monthly，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 1924，原创研究文献占比: 0.00%，自引率:1.20%， Gold OA占比: 18.73%
平均审稿周期	网友分享经验：平均4.3个月
平均录用比例	网友分享经验：多是约稿

Chemical Reviews

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